Focused Ultrasound
Conditions
Keywords
Ultrasound, Neuromodulation, Focused Ultrasound
Brief summary
Focused ultrasound at low intensities is a form of neuromodulation with high spatial resolution that can be applied invasively or non-invasively using acoustic energy to affect neuronal activity. The purpose of this study is to better understand the effects of low intensity focused ultrasound (FUS) on the central nervous system. Specific patient populations within UVA health system are undergoing treatment that provide unique opportunities to study these effects.
Detailed description
Focused ultrasound (FUS) at low intensities is a form of neuromodulation with high spatial resolution that can be applied invasively or non-invasively using acoustic energy to affect neuronal activity. In this study the investigators intended to use specific patient populations to investigate the effects of FUS on different areas of the central nervous system (CNS). Each of our patients groups is undergoing a unique procedure at University of Virginia that will provide us different insights into the CNS. (1) Patients receiving an awake or asleep craniotomy for brain tumors and/or epilepsy will undergo a brain mapping procedure using electrical stimulation as a part of their normal care. The research procedures will duplicate this mapping with an invasive FUS mapping. (2) Patients undergoing long term monitoring for epilepsy will receive a non-invasive form of FUS stimulation which will be measured by their EEG cap and intracranial electrodes which are a part of their normal care. (3) Patients undergoing high intensity FUS treatment for tremor will be asked to wear a research provided EEG cap while undergoing a non-invasive low intensity FUS research procedure and changes in their tremor will be monitored. (4) Patients undergoing Deep Brain Stimulation (DBS) treatment for tremor will receive a non-invasive FUS stimulation observed through their newly implanted electrode. (5) Patients receiving a spinal surgery will undergo a spinal stimulation using electrical stimulation as a part of their normal care. The research procedures will duplicate this with an invasive FUS stimulation.
Interventions
OTHERFocused Ultrasound
Low intensity focused ultrasound is sound energy stimulation at a low intensity of 1-30 W/cm2
Sponsors
University of Virginia
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Intervention model description
Within subjects design of focused ultrasound and control
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Be a patient receiving a treatment or surgical procedure specified below: * Receiving a Craniotomy with brain mapping * Receiving treatment or monitoring for Epilepsy * Receiving either FUS or DBS treatment for Tremor * Receiving a Spinal Surgery for stimulator placement * Able to provide informed consent * Must speak English * Age 18-85
Exclusion criteria
* Not receiving one of the specified inclusion procedures * Unable to provide consent * Women who self-report pregnancy * Patients who are currently incarcerated
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Electrophysiological Changes as a result of Ultrasound | baseline, immediately after ultrasound (same day, approximately 5-10 minutes after baseline) | Each participant group has different type of electrophysiological recording depending on the type of procedure. Recordings will include a baseline, during ultrasound, and/or post-ultrasound electrophysiology. |
Countries
United States
Contacts
Primary ContactSarah Adams
Outcome results
None listed