Cardiac Output, Low, Critical Illness, Surgery
Conditions
Brief summary
Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.
Detailed description
Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.
Interventions
PROCEDUREPEEP increase
PEEP increase +5 to +15 cmH2O. PLR at 30 degrees.
Sponsors
University Hospital Dubrava
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Mechanically ventilated and sedated patients admitted to the ICU after major abdominal surgery
Exclusion criteria
* Heart failure NYHA III or more * Severe obstructive or restrictive lung disease * Hypotension with MAP \< 60 mmHg * Tachycardia \> 140 beats / min
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stroke volume increase after passive leg raise | Within 30 seconds after PLR | Patients who have a stroke volume (measured in ml) increase of 7% or more after passive leg raise will be considered volume responsive. After the patients have been stratified into volume responders and volume non-responders, sensitivity and specificity of PEEP induced increase in CVP and pulse pressure variation will be assessed and further statistical analysis will be performed. |
Countries
Croatia
Contacts
Primary ContactAndrej Šribar, MD, PhD
Outcome results
None listed