Aluminum Phosphid Poisoning, Cardiotoxicity
Conditions
Keywords
tropinin, CKmb, cardiotoxicity
Brief summary
Aluminum phosphide (AlP) or rice tablet is a cheap pesticide. When it comes in contact with acid (gastric acid) or moisture, it releases phosphine (PH3) gas. The heart,lungs, liver are the main targets in acute Aluminum phosphide (AlP) poisoning. Most deaths occur due to cardiovascular toxicity.
Detailed description
Aluminium phosphide is a potent respiratory chain enzyme inhibitor. Its most important effect is the inhibition of cytochrome c oxidase. The inhibition of cytochrome c oxidase and other enzymes leads to the generation of superoxide radicals and cellular peroxides , and subsequent cellular injury through lipid peroxidation and other oxidant mechanisms. It stimulates the production of hydrogen peroxide and reactive oxygen species, malonyldialdehyde (MAD), increases superoxide dismutase and inhibits catalase, peroxidase and glutathione . Oxidative stress is one of the main mechanisms of action of aluminium phosphide toxicity
Interventions
DIAGNOSTIC_TESTserum tropinin, serum CKmb
early detection of myocardial injury, allowing application of acute cardiac shock and cardiogenic shock
Sponsors
Assiut University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
ALP poisoned cases * admitted with free ECG
Exclusion criteria
concomitant ingesion of other drugs or toxins \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury | 6 months | assess serum tropinin and CKmb as biomarkers for early detection of ALP induced myocardial injury |
Countries
Egypt
Outcome results
None listed