Multiple Myeloma
Conditions
Keywords
free light chains, healthy twins
Brief summary
The objective of this study is to recruit healthy adult identical and fraternal twins for the collection of one teaspoon of blood to be sent to the Clinical Lab at San Francisco General Hospital. The serum will be tested to determine the reference range for free light chains.
Detailed description
Serum free light chains are used to assist in the diagnosis of multiple myeloma. The test measures kappa (K) and lambda (L) chains, and the calculation of the ratio of kappa to lambda (K/L). Previous studies have shown that the K/L ratio does not change over time (1 year). The hypothesis of this study is that healthy twins will have a K/L ratio that are close to each other in value, suggesting that this ratio is genetically linked.
Interventions
OTHERFree light chains
Blood samples will be collected and analyzed
Sponsors
University of California, San Francisco
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Masking description
The participant will not be given the results of the free light chain result
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy subjects 18-80 years. * Must be an identical or fraternal twin (both must be recruited)
Exclusion criteria
* Symptoms suggestive of multiple myeloma (e.g., renal insufficiency, anemia, bone pain) -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Free light chain reference range | One month after the completion of the enrollment | Determination of the normal range for free light chains |
Countries
United States
Outcome results
None listed