Interactions of Brain Regions in Visuomotor Adaptation

Functional Interaction of Thalamus, Basal Ganglia, and the Cerebellum in Visuomotor Adaptation

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04190940

Enrollment

Registered

2019-12-09

Start date

2019-04-18

Completion date

2021-04-17

Last updated

2019-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Brain Stimulation, High Intensity Focused Ultrasound

Keywords

Ultrasound, Thalamus, Cerebellum, Basal Ganglia, Deep Brain Stimulation, High Intensity Focused Ultrasound

Brief summary

The purpose of this study is to better understand the roles the cerebellum, basal ganglia, and thalamus play in motor learning. Patients undergoing High Intensity Focused Ultrasound (HIFU) treatment will be receiving an ablation procedure to their thalamus as a part of their medical procedure. Participation in this study will include completing a behavioral task before and after the procedure to see how motor learning task performance differs with and without the thalamus. Similarly, patients undergoing Deep Brain Stimulation (DBS) treatment will have an electrode implanted in their thalamus as a part of their medical procedures. Participation in this study will include completing the motor learning task performance on and off thalamic electrical stimulation.

Interventions

BEHAVIORALBehavioral Assessment

Patients will be asked to complete the behavioral assessment before and after their HIFU treatment or on and off their DBS treatment.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Be a patient receiving either high intensity focused ultrasound treatment or deep brain stimulation treatment for Tremor * Able to provide informed consent and complete study procedures * Must speak English * Age 18-85

Exclusion criteria

* Not receiving one of the specified inclusion criteria * Unable to provide consent or complete study procedures * Women who self-report pregnancy * Patients who are currently incarcerated

Design outcomes

Primary

Measure	Time frame	Description
Performance Error on Visuomotor Task	baseline, a week after HIFU treatment, several weeks after DBS implantation	The visuomotor task has practice, baseline, and experimental trials. Performance on the task will be compared between groups (HIFU treatment and DBS treatment) before and after treatment.

Countries

United States

Contacts

Primary ContactSarah Adams

neuromodlab@hscmail.mcc.virginia.edu4342434319

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026