Eye Abnormalities, Preterm Birth, Visual Impairment
Conditions
Keywords
Moderate-to-late preterm
Brief summary
During recent years, the interest in studying the risks of being born moderate-to-late preterm (MLP), defined as birth between gestational week 32 to 36, has increased. Today the investigators know that morbidity and mortality are significantly higher in these individuals compared to individuals born full-term. However, few studies have focused on the development of the eye in MLP individuals. The purpose of the study is to evaluate eye morphology and visual function in relation to growth, metabolism, blood pressure, neuropsychiatric factors, and quality of life in adolescents born MLP. The results of the examinations will be compared to an age-matched control group. The study will evaluate the structural, functional, and metabolic aspects of the eye with the hypothesis that early eye abnormalities may detect the risk of developing metabolic and cardiovascular diseases.
Interventions
OTHERStructural, functional and metabolic eye examinations
Structural, functional and metabolic eye examinations
Sponsors
Vastra Gotaland Region
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* Born moderate-to-late preterm. * Born in Gothenburg, Sweden. * Born between years 2002 and 2004.
Exclusion criteria
* Chromosomal abnormalities. * Syndromes. * Severe malformations. * Asphyxia. * Language difficulties. * Psychosocial problems at birth. * Severe maternal illness.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Optic disc area. | Through study completion, an average of 6 months | Optic disc area measured with Optical coherence tomography (OCT, Topcon). |
| Visual acuity. | Through study completion, an average of 6 months. | Visual acuity measured with Early Treatment Diabetic Retinopathy Study (ETDRS) scores. |
| Blood pressure. | Through study completion, an average of 6 months. | Systolic and diastolic blood pressure measured with blood pressure cuffs. |
| Blood concentration of Hemoglobin A1c (HbA1c). | Through study completion, an average of 6 months. | Blood samples of HbA1c. |
| Autism Spectrum Screening Questionnaire (ASSQ). | Through study completion, an average of 6 months. | The ASSQ consists of 27 items and is scored using a likert scale, with the following alternatives: not true (0 points), somewhat true (1 point) and certainly true (2 points). |
| Pediatric Quality of Life Inventory (PedsQL). | Through study completion, an average of 6 months. | PedsQL is a questionnaire measuring health-related quality of life in children and adolescents aged 2 to 18 years. It consists of 23 items including physical functioning (8 items), emotional functioning (5 items), social functioning (5 items) and school functioning (5 items). It has a 5-point response scale: never a problem (0 points), almost never a problem (1 point), sometimes a problem (2 points), often a problem (3 points), almost always a problem (4 points). |
| Weight. | Through study completion, an average of 6 months | Weight measured in kilograms. |
| The Swanson, Nolan, and Pelham Rating Scale (SNAP-IV). | Through study completion, an average of 6 months. | Screening questionnaire for attention deficit hyperactivity disorder (ADHD) consisting of 26 items rated on a 4-point scale: not at all (0 points), just a little (1 point), quite a bit (2 points) and very much (3 points). |
| Refraction. | Through study completion, an average of 6 months. | Visual refraction measured with an autorefractor (Topcon). |
| Height. | Through study completion, an average of 6 months. | Height measured in meters. |
Countries
Sweden
Outcome results
None listed