Anesthesia, Tolerance
Conditions
Keywords
Anesthesia, Electroencephalogram, Spectral analysis
Brief summary
Deep sedation or general anesthesia is frequently required for infant that need radiotherapy to treat malignancies. As radiation therapy usually consist of several sessions, these patients are exposure to several consecutive anesthetic exposures (e.g. for some central nervous system tumors 30 sessions of radiotherapy are required). In our center, this 30-min anesthetic exposure are with sevoflurane. Considering that repeated daily exposure to such potent drugs, as general anesthetics, may induce tolerance, it is reasonable to explore whether this phenomenon is occurring in this population. The aim of this observational study was to determine if a repeated exposure to sevoflurane is associated with the development of clinical and electroencephalographic tolerance. We will enroll 16 pediatric patients, and we will measure the time needed to appropriately place the laryngeal mask (clinical effect) and we also will compare the electroencephalographic signal under anesthesia across the different sessions (electroencephalographic effect).
Detailed description
The purpose of this study is to evaluate the development of tolerance to sevoflurane in children undergoing repeated drug exposure. We will evaluate the development of tolerance in two ways: Clinical: as the time needed to perform the inhalation induction, with a standardized protocol. Electroencephalographic: we will record every 3 sessions the electroencephalographic activity of the patients. We will perform classical spectral analysis, and coherence analysis as well. This observational study will be mainly exploratory since there are no other previous report in this topic
Interventions
DRUGSevoflurane
Describe how a reiterative anesthesia exposure could induce tolerance to the anesthetic.
Sponsors
University of Chile
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
10 Months to 12 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing radiotherapy * Requiring general anesthesia
Exclusion criteria
* Previous Radiotherapy * Malignant Hyperthermia history
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Theta power in the EEG spectrum under anesthesia | Last session of radiotherapy (compare to first session) - Up to 6 weeks | Theta power obtained from the EEG signal, with the patient under general anesthesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to Laryngeal Mask insertion | Last session of radiotherapy (compare to first session) - Up to 6 weeks | The time in seconds between the induction beginning and the correct laryngeal mask placement |
| Alpha power in the EEG spectrum under anesthesia | Last session of radiotherapy (compare to first session) - Up to 6 weeks | Alpha power obtained from the EEG signal, with the patient under general |
| Coherence | Last session of radiotherapy (compare to first session) - Up to 6 weeks | Coherence between frontal electrodes in bands of the spectrum |
Countries
Chile
Outcome results
None listed