Kidney Diseases
Conditions
Brief summary
Endothelial progenitor cells derived from and delivered to the renal vasculature may be stimulated to initiate differentiation programs during episodes of injury. It is hypothesized that endothelial progenitor cells from the kidney can transition to a phenotype that promotes endothelial repair.
Detailed description
This is an interventional study involving patients that have a diagnosis of chronic kidney disease. Patients will have at least stage 3 chronic kidney disease stage or greater. Kidney-derived endothelial progenitor cells will have been obtained using associated protocols that are currently approved by the Partners Human Research Committee.
Interventions
BIOLOGICALendothelial progenitor cell
Kidney-derived endothelial progenitor cells will be delivered percutaneously to the kidney blood supply.
Sponsors
Brigham and Women's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Open label single arm study
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Enrolled patients will have endothelial progenitor cells previously acquired.
Exclusion criteria
* Patients without previously acquired endothelial progenitor cells will be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Safety of progenitor cell delivery | 180 days | Serum creatinine will be measured after cell delivery |
Contacts
Primary ContactAndrew M Siedlecki, MD
Outcome results
None listed