Living Donor Liver Transplantation
Conditions
Keywords
Ascites, Albumin, Hartmann's solution, Postoperative ileus
Brief summary
The aim of this study is to evaluate difference in the rate of recovery of intestinal motility according to different ascites replacement strategy after living donor liver transplantation.
Interventions
DRUGAscites replacement with albumin and hartmann's solution
Combined strategy for ascites replacement * 30% of ascites: replacement with 5% albumin * 40% of ascites: replacement with Hartmann's solution
DRUGAscites replacement with hartmann's solution
Hartmann's solution only strategy for ascites replacement \- 70% of ascites: replacement with Hartmann's solution
Sponsors
Seoul National University Hospital
GC Pharma
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults (19 years or older) * Elective living donor liver transplantation
Exclusion criteria
* Previous abdominal surgery * Renal failure requiring renal replacement therapy * Contraindications for 5% albumin use 1. Condition with potential risk caused by increased circulating plasma (heart failure, renal failure combined with oliguria, pulmonary edema) 2. Hemolytic anemia * Contraindications for Hartmann solution 1. Progressive lactic acidosis 2. Hypervolemia 3. Hypernatremia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to 1st flatus | within 4 weeks | Interval between SICU admission and 1st flatus |
| Time to 1st diet | within 4 weeks | Interval between SICU admission and 1st diet |
Countries
South Korea
Outcome results
None listed