Glycemic Index
Conditions
Keywords
Juice, Fiber
Brief summary
Compare the effects of whole orange, orange juice alone, and orange juice with added orange pomace fiber, and whole apple, apple juice alone, and apple juice with added apple pomace fiber, on 2h glycemic response.
Interventions
OTHERFruit
Phase 1 is 227g of orange fruit, Phase 2 is 230g of apple fruit
OTHERFruit juice
Phase 1 is 250g of orange juice, Phase 2 is 235g of apple juice
OTHERFruit juice plus fiber
Phase 1 is 157g of orange juice + 100g of orange pomace fiber (39% pomace by weight), Phase 2 is 129g of apple juice + 106g of apple pomace fiber (45% pomace by weight)
Sponsors
PepsiCo Global R&D
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Cross-over
Eligibility
Sex/Gender
ALL
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 20-24.9 kg/m2 and weight \>=110 lbs at screening * Willing to maintain usual physical activity pattern and exercise level * Willing to follow instructions for compliance with dietary restrictions, dosing and visits * In good health based on medical history * Willing to avoid alcohol for 24 hrs prior to visits * Willing to maintain stable dose of vitamins, minerals, supplements, and medications not interfering with study outcomes including birth control for the study * Understands procedures, signs informed consent and authorization for release of relevant protected health information and is willing to complete study procedures
Exclusion criteria
* Fasting finger stick glucose \>100 * Uncontrolled hypertension * Major trauma or surgical event within 2 months of Visit 1 * Weight change \> 4.5 kg within 2 months, taking weight loss drugs, bariatric surgery, or other weight reduction surgery (liposuction, laser fat removal, etc.) * History or presence of clinically important endocrine, cardiovascular, pulmonary, bilary or gastrointestinal disorders that could interfere with the interpretation of study results * History or presence of cancer in past 2 yrs except for non-melanoma skin cancer * History of extreme dietary habits (Atkins, etc.) * History of eating disorder * Known intolerance or sensitivity to any of the ingredients in the study products * Subject has used medications know to influence carbohydrate metaboism 2 weeks prior to visit and throughout the study * Subject is taking systemic steroids, extreme alcohol use or drug user * Vein access score \< 7 * Pregnant, planning to become pregnant, or lactating * Current smoker or smoked within past 2 yrs * Has not participated in another clinical trial for past 30 days or another PepsiCo study in past 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose | 0-120 minutes | Cmax, plasma |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Glucose | 0-120 minutes | iAUC, plasma |
| Insulin | 0-120 minutes | iAUC, plasma |
Countries
United States
Outcome results
None listed