Diuretic Abuse
Conditions
Keywords
furosemide, hydrochlorothiazide, residual renal function
Brief summary
Background.The objective of the present study is to verify whether using diuretics will improve either blood pressure or fluid overload in maintenance hemodialysis patients with residual diuresis kidney function.
Detailed description
Methods.46 maintenance hemodialysis patients will be given three stages of diuretic intervention: 100mg furosemide every day for 1 month, 200mg furosemide every day for 1 month, and 100mg furosemide combined with 25mg hydrochlorothiazide every day for 1 month. The 24-hour urine volume, 24-hour urine sodium, 24-hour urine potassium, blood pressure, OH(overhydration) and dry weight will be collected. OH will be measured by bioelectrical impedance.
Interventions
DRUGFurosemid hydrochlorothiazide
furosemide 100mg for one month;furosemide 200mg for one month;furosemide 100mg and hydrochlorothiazide 25mg for one month;
Sponsors
Capital Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* maintenance hemodialysis patient * unrine volume more than 100ml.
Exclusion criteria
* myocardial infarction; * unrine volume less than 100ml.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine volume increasing after diuretic use in maintenance hemodialysis patients with residual renal function | up to 16 months |
Countries
China
Contacts
Primary ContactYunfei Ding, Master
Backup Contactzhoucang Zhang, Master
Outcome results
None listed