Aerobic Exercise, Diabetes Mellitus, Type 2, Genetic Response
Conditions
Keywords
Type 2 diabetes mellitus, exercise, aerobic
Brief summary
The aim of this study is to compare the effects of high intensity interval exercise and moderate intensity continuous exercise on some genetic molecules in patients with type 2 diabetes mellitus.
Detailed description
Volunteers with type 2 diabetes mellitus will be evaluated in terms of any contra-indication that will restrain them from making exercise. 90 male or female volunteers who are suitable in terms of inclusion/exclusion criteria will be invited for the study. Volunteers will be randomly distributed to one of the 3 groups. Each group will contain 30 participants. 1. group will make aerobic exercise which is in the form of high intensity interval exercise 2.group will make aerobic exercise which is in the form of moderate intensity continuous exercise 3. Control group. Exercise groups will be cycling under observation in the hospital setting. Control group will make simple stretching exercises at home. Participants will be requested to complete a 3 months of exercise. They will be evaluated before and at the end of the 3 months of exercise with blood tests to measure genetic molecules related with metabolism.
Interventions
OTHERexercise
aerobic exercise
Sponsors
Pamukkale University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Masking description
Participants wil be making exercise. It is not possible to make participants blinded to the study.
Intervention model description
The study has 3 arms
Eligibility
Sex/Gender
ALL
Age
30 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
Clinica diagnosis of type 2 Diabetes mellitus less than 10 years and more than 1 year. * must have appropriate medical therapy and diet. * must not be treated with insulin. * must be exercising less than 210 minutes/ week
Exclusion criteria
* prominent cardiovascular disease * coronary artery disease * moderate to severe valvular disease * atrial fibrillation * untreated hypertension * congenital heart disease * retinopathy * neuropathy * macro albuminuria * cerebrovascular disease * ejection fraction less than 40 * body mass index greater than 35. * prominent ischemic changes in EKG at rest or during exercise. * cigarette or alcohol addiction * on drugs that interferes with body fat distribution (such as insulin, thiazolidinediones
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| genetic molecules | 12 weeks | HbA1c level in the serum |
Countries
Turkey (Türkiye)
Outcome results
None listed