Digestive System Fistula, Intestinal Fistula, Intestinal Perforation, Liver Transplantation
Conditions
Keywords
Risk Factors, Survival
Brief summary
Liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. However some patients develop intestinal perforations for which the prognosis is poor. The aim of the study is to evaluate the risk factors of intestinal perforations using a retrospective study scheme.
Detailed description
Liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. However some patients develop intestinal perforations for which the prognosis is poor. The aim of the study is to evaluate the risk factors of intestinal perforations using a retrospective study scheme. Previous studies have shown a possible implication of drugs or medical history or intraoperative complications. The investigators aim to describe the other possible risk factors (such as portal vein clampage) and the type of surgery done after the diagnosis and its impact on survival as well.
Interventions
PROCEDURELiver transplantation
Liver transplantation
Sponsors
Université Montpellier
University Hospital, Montpellier
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients having received an orthotopic liver transplantation in the Montpellier University Hospital from 2014 to 2019 * for the group Perforation: patients having during the follow-up a complication such as intestinal perforation. The complete list uses the ICD-10 codes for intestinal perforation, esophageal perforation, duodenal perforation etc.
Exclusion criteria
* No
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the total length of stay | 1 month | Evaluate the total length of stay |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluate the occurrence of death | 1 month, 3 months, 6 months. | Evaluate the occurrence of death |
| Evaluate the total number of complications | 1 month, 3 months, 6 months. | Evaluate the total number of complications |
| Evaluate the number of perforations | 1 month, 3 months, 6 months. | Evaluate the number of perforations |
| Evaluate the quality of life | 1 month, 3 months, 6 months. | Evaluate the quality of life |
| Evaluate the occurrence of an acute or chronic rejection | 1 month, 3 months, 6 months. | Evaluate the occurrence of an acute or chronic rejection |
Countries
France
Outcome results
None listed