Protein C Deficiency
Conditions
Keywords
ghrelin, growth hormone, protein C deficiency, appetite
Brief summary
In rodents with protein C deficiency elevated levels of ghrelin has been observed. The purpose of this study is to investigate if patients with protein C deficiency also have elevated levels of ghrelin, and if so, how this affects the patients. 30 patients with protein C deficiency and 30 healthy BMI and gender matched controls are recruited. Bloodsamples are taken in order to measure ghrelin and GH levels and other metabolic parameters. The patients and controls are also asked to answer a questionaire regarding appetite. If patients with protein C deficiency have higher levels of ghrelin than the general population, this will lead to new studies that will perhaps help us understand the importance of ghrelin in humans.
Interventions
GENETICProtein C deficiency
The effect of protein C deficiency on ghrelin levels are investigated.
Sponsors
University of Aarhus
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* protein C deficiency or healthy subjects * age 18-70 * BMI 18-35 * written statement to join the study
Exclusion criteria
* chronic illness, apart from protein C deficiency and lifestyle diseases * everyday medication apart from statins, oral diabetes medication and antihypertensive drugs. * blood donation within three months prior to the investigation. * Alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| acyl ghrelin and des acyl ghrelin measured in mg/dl | 6 month |
Secondary
| Measure | Time frame |
|---|---|
| Growth hormone measured in pmol/L | 6 month |
Contacts
Primary ContactSascha S Horup, MD
Backup ContactRakel F Johansen, MD
Outcome results
None listed