Energy Expenditure, Metabolism, Non-invasive Ventilation
Conditions
Brief summary
Before inclusion in the trial. Careful medical history and medication use will be asked. Once included, 5 healthy subjects non-invasive ventilation(V60, Philips, Eindhoven, The Netherlands) will be administered at a level of positive end expiratory pressure (PEEP) of 4 cmH2O and without additional inspiratory support. Inspiratory support will then increase by 2 cmH2O every 2 minutes until 8 cmH2O is achieved for 2 minutes. The energy expenditure is measured using indirect calorimetry (Q-NRG®, Cosmed, Italy). To measure respiratory effort, the reversed RPE-scale was created for the purpose of the study. It uses the validated rate of perceived exertion scale (RPE-scale) which was altered by adding a reversed part. This could result in a score of -10 (no respiratory effort) until +10 ( maximal respiratory effort) where 0 represents the basal respiratory condition. Monitoring of heart rate, blood pressure and cardiac output will be done ( Nexfin®, BMEYE, Amsterdam, The Netherlands). After termination of the study clinical observation by principal investigator or co-investigator will be done for 15 minutes or until all side effects have worn off. If no side effects are observed, subjects will be released.
Interventions
DEVICEnon-invasive ventilation
non-invasive ventilation will be performed on every subjects
Sponsors
Universitair Ziekenhuis Brussel
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteers
Exclusion criteria
* pregnancy * prisoners * participation in interventional study in last 2 weeks before enrolment * Current ongoing disease: * Cardiac * respiratory * ear * nose * gastro-intestinal * neurological * psychiatric
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy expenditure | during non-invasive ventilation | in kcal/day Energy expenditure will be measured using indirect calorimetry during different settings of non invasive ventilation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| respiratory rate | during non-invasive ventilation | in breaths/min |
| systolic and diastolic bloodpressure | during non-invasive ventilation | in mmHg |
| cardiac output | during non-invasive ventilation | in liter/min |
| reversed combined rate of perceived exertion scale | during non-invasive ventilation | no unit, range: \[-10 , +10\] based on an existing scale of perceived exertion, a reverse part was added to be able to measure an improvement of respiratory exercise compared to normal state. |
| O2 consumption of the body (VO2) | during non-invasive ventilation | in ml/min |
| Respiratory quotient | during non-invasive ventilation | no unit |
| CO2 production of the body ( VCO2) | during non-invasive ventilation | in ml/min |
Countries
Belgium
Outcome results
None listed