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Hypermethylation of VTRNA2-1 Promoter in HCC Outcome

Differential Hypermethylation Status of the VTRNA2-1 Promoter in Hepatocellular Carcinoma as an Independent Factor After Partial Hepatectomy

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04177316
Enrollment
92
Registered
2019-11-26
Start date
2018-12-01
Completion date
2019-11-15
Last updated
2019-11-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular Carcinoma Resectable

Keywords

VTRNA2-1 promoter, recurrence, methylation

Brief summary

The clinic-pathological data were retrieved from the cancer registry database from the Cancer Center of Chang Gung Memorial Hospital, Linkou branch. Of the 92 HCC patients with partial hepatectomies enrolled. The biological specimen was studied with approval.

Detailed description

This study was approved by the Institute Review Board (IRB) of Chang Gung Memorial Hospital, Linkou Branch (IRB 201801969B0). The clinic-pathological data were retrieved from the cancer registry database from the Cancer Center of Chang Gung Memorial Hospital, Linkou branch. Of the 92 HCC patients with partial hepatectomies enrolled, all patients had curative hepatectomy and those with different cancers were excluded. HCC tumor tissue and normal tissue, 3 cm from the tumor margin, were stored immediately in a -80 degree freezer at the Central Biobank of Chang Gung Memorial Hospital. The personal information was protected with decoding and registered with number.

Interventions

None listed

Sponsors

Chang Gung Memorial Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
20 Years to 85 Years

Inclusion criteria

subjects with pathologic diagnosis of hepatocellular carcinoma curative partial hepatectomies

Exclusion criteria

history of different malignant disease. subjects cannot be treated with curative surgery.

Design outcomes

Primary

MeasureTime frameDescription
disease free survival (DFS)a monthThe length of time from curative hepatectomies treatment and recurrence or mortality

Secondary

MeasureTime frameDescription
Overall survivala monthThe length of time from hepatectomies treatment for HCC and still alive.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026