Attention Deficit Hyperactivity Disorder
Conditions
Keywords
Transcranial Direct Current Stimulation
Brief summary
To determine the cognitive and neurophysiological dose-response relationships of anodal tDCS to the left DLPFC as a function of absolute current intensity, individualized E-field intensity, and stimulation duration.
Detailed description
To determine the cognitive and neurophysiological dose-response relationships of anodal tDCS to the left DLPFC as a function of absolute current intensity, individualized E-field intensity, and stimulation duration.
Interventions
DEVICETranscranial Direct Current Stimulation
In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes.
Sponsors
Massachusetts General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
(Patients) 1. Male and female outpatients 18-55 years of age 2. A diagnosis of ADD/ADHD or meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria. 3. Patient will be either off stimulant medications or, if undergoing treatment with stimulants, will be asked to discontinue two days prior to the experiment, under physician-guided protocol, and allowed to resume afterwards. Subjects may resume stimulant use between the two study visits so long as they discontinue use two days prior to the second study visit. If fatigue is problematic in subjects discontinuing medication, they will be allowed to continue with the study if they are able to follow the suggested taper plan (50% of the dose day one, 25% dose day 2, stop day of visit (day 3)). 4. If on non-stimulant medications, dose must have been stable for at least 4 weeks.
Exclusion criteria
(Patients) 1. Contraindication to tDCS: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, VP shunt, pacemakers, pregnancy. 2. Active substance dependence (except for tobacco). 3. Pregnant or nursing females. 4. Inability to participate in testing procedures. Inclusion Criteria (Healthy Control) 1\. Male and female outpatients 18-55 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Accuracy and Reaction Time in Attention and Working Memory | Change Before and After Stimulation on Each of the Four Visits, Average of 2-6 Weeks | Measured using Eriksen Flanker Task (EFT) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amplitude of Electroencephalogram (EEG) Event Related Potentials | Change Before and After Stimulation on Each of the Four Visits, Average of 2-6 Weeks | Measure of amplitude related to stimulus |
Countries
United States
Outcome results
None listed