Cystic Fibrosis in Children, Exercise Capacity
Conditions
Keywords
pulmonary exacerbation
Brief summary
The aim of this study to investigate and compare functional capacity with different tests and to evaluate the relationship between functional capacity and quality of life during acute pulmonary exacerbation in children with cystic fibrosis. Exercise tests associated with prognostic values in CF patients and decreased exercise capacity has been correlated with a reduction in health-related quality of life. Pulmonary functions, functional capacity and quality of life will examine in this study.
Detailed description
This study will be participated children with cystic fibrosis who will diagnosed acute pulmonary exacerbation. Patients' pulmonary function test, functional capacity will be assess and record at hospital admission and hospital discharge and outpatient clinic control. Quality of life will be evaluated at only outpatient clinic control . Pulmonary function test will be assessed with spirometry, functional capacity will be evaluated with 1-minute sit to stand test and 3-minute step test. And quality of life will be evaluated Cystic Fibrosis Questionnaire-Revised (CFQ-R).
Interventions
DIAGNOSTIC_TEST1-minute sit to stand test
Childrens will complete 1-minute sit to stand test and 3 minute step test and quality of life questionnaire.
Sponsors
Hacettepe University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Childrens with CF diagnosed between 7-18 years of age and hospitalized due to acute pulmonary exacerbation will be included in the study.The diagnosis of acute pulmonary exacerbation will be established by Fuchs criteria.
Exclusion criteria
* Patients with allergic bronchopulmonary aspergillosis (ABPA) who were treated with systemic steroid therapy and noninvasive mechanical ventilation support will not be included in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 1 minute sit to stand test (STS) repetitions | November 2019- January 2021 | number of STS completed at hospital admissions, hospital discharge and outpatient time |
| 3 minute step test | November 2019- January 2021 | number of completed step at hospital admissions, hospital discharge and outpatient time |
| pulmonary functions | November 2019- January 2021 | pulmonary functions assessment via spirometry |
| Quality of life assesment | November 2019- January 2021 | Cystic Fibrosis Questionnaire-Revised (CFQ-R) included 4 different age. These versions are teen/adult version,child version,parent version for children, preschool version. Scores range from 0 to 100, with higher scores indicating better health. This questionnaire will be filled only once. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| quadriceps fatigue | November 2019- January 2021 | difference pre and post test quadriceps fatigue with Visual Analogue Scale (VAS).Scores range from 0 to 10, with higher scores indicating worse outcome. |
| Maximal heart rate | November 2019- January 2021 | maximal heart rate during 3-minute step test |
| hospitalization frequency | 1 year | number of hospitalization per year |
| fatigue | November 2019- January 2021 | difference pre and post test fatigue with Visual Analogue Scale (VAS).Scores range from 0 to 10, with higher scores indicating worse outcome. |
| Heart rate | November 2019- January 2021 | difference pre and post test heart beat number |
| oxygen saturation | November 2019- January 2021 | difference pre and post test percentage of oxygen saturation |
| dyspnea | November 2019- January 2021 | difference pre and post test breathlessness with Visual Analogue Scale (VAS).Scores range from 0 to 10, with higher scores indicating worse outcome. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactKübra Kılıç, PhD Student
Backup ContactHacettepe University
Outcome results
None listed