Diverticula, Diverticular Disease, Diverticulitis
Conditions
Keywords
colonoscopy, diverticular disease
Brief summary
Confocal laser endomicroscopy detects inflammatory markers undetectable during high definition endoscopy. The investigators aimed to evaluate the role of peridiverticular and colonic mucosa inflammation in the prediction of the complicated diverticular disease using confocal laser endomicroscopy evaluation in the peridiverticular area in consecutive patients.
Detailed description
Diverticular disease of the colon is a prevalent condition in the western hemisphere. Currently there is an endoscopic classification system for classifying diverticular disease; however, white light endoscopic fails to accurately detect inflammation. Confocal laser endomicroscopy offers a real-time, in-vivo evaluation of the colonic mucosa, with an adequate correlation to histological findings. The investigators aimed to evaluate the role of peridiverticular and colonic mucosa inflammation in the prediction of complicated diverticular disease.
Interventions
DIAGNOSTIC_TESTProbe-based confocal laser endomicroscopy evaluation
Colonoscopy with confocal laser endomicroscopy evaluation of the peridiverticular and colonic mucosa on patients with diverticular disease
Sponsors
Instituto Ecuatoriano de Enfermedades Digestivas
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Above 18 years old * Writeen informed consent provided. * Endoscopic visualization of diverticular disease during colonoscopy. * Adequate bowel preparation BBPS \>2 in each colon segment
Exclusion criteria
* Under 18 years old. * Refuse to sign written informed consent. * Pregnancy or nursing. * Previous colorectal surgery * History of colorectal cancer * Known allergy to fluorscein * Uncontrolled coagulopathy * History of complicated diverticular disease * Patients with inflammatory bowel disease * Patients with severe comorbidities: kidney and liver failure * NSAIDs and antibiotics two weeks prior enrollment * Historyh of alcohol or drug abuse * Patients with severe mental illness * Patients with incomplete evaluation of the colon
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ocurrence of complicated diverticular disease | up to 12 months | To predict the ocurrence of complications in colonic diverticular disease based on pCLE findings |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| peridiverticular and colonic mucosa inflammation based on pcle | index procedure | • Presence of peridiverticular and colonic mucosa inflammation based on confocal laser endomicroscopy. |
| DICA classification | index procedure | DICA classification system in all patients during initial colonoscopy. |
| ocurrence of complicated diverticular disease | 12 months and 24 months | Ocurrence of complicated diverticular disease, assed up to 12 months after enrollment based on Hinchey Classification (III-IV). |
| ocurrence of surgical intervention | 12 months and 24 months | • Ocurrence of surgical invertenvion for the management of complicated diverticular disease |
Countries
Ecuador
Outcome results
None listed