Evaluation of Inflammatory Markers and Periodontal Viruses on Periodontitis Patients With CAD

Evaluation of Demographic Variables, Clinical Parameters, Inflammatory Markers and Viruses in Periodontitis Patients With Coronary Artery Diseases

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04172870

Enrollment

240

Registered

2019-11-21

Start date

2018-11-15

Completion date

2020-12-01

Last updated

2020-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis, Coronary Artery Disease

Keywords

Ebstein Barr Virus, Cytomegalovirus, Herpes Simplex Virus, Pentraxins, Toll Like Receptors

Brief summary

To assess and compare the demographic variables, periodontal parameters, cardiac parameters and the expression of periodontal viruses (CMV, HSV and EBV) and inflammatory biomarkers(PTX-3, TLR-2 & TLR-4) in periodontally healthy and generalized periodontitis patients with and without coronary artery disease(CAD).

Detailed description

A total of 240 subjects will be recruited based on the power of the study. The selected subjects will be divided into four groups based on the inclusion and exclusion criteria. 1. GROUP I: 60 healthy subjects ( No generalised periodontitis and no CAD) 2. GROUP II: 60 generalised periodontitis subjects without CAD 3. GROUP III: 60 CAD subjects without generalised periodontitis 4. GROUP IV: 60 subjects with Generalised periodontitis and CAD Sub-gingival plaque samples will be collected from the subjects of all the four groups. Coronary artery plaque samples will be collected from the patients who were indicated for coronary artery bypass graft surgery (CABG) among group III and group IV. The demographic variables , periodontal parameters , cardiac parameters , expression of periodontal viruses and inflammatory biomarkers will be measured in all four groups ,

Interventions

DIAGNOSTIC_TESTMolecular analysis

RT- PCR

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

30 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

1. Patients willing to participate in the study. 2. Patients with 30 to 65 years of age group 3. Both genders 4. Patients should have minimum of 10 natural teeth. 5. In case of group III and IV patients with coronary heart disease to be included.

Exclusion criteria

1. Patients who had undergone periodontal therapy within the previous 6 months. 2. Type I and II Diabetes mellitus 3. Sarcoidosis patients. 4. Carcinoma patients. 5. Rheumatic arthritis patients. 6. Tuberculosis patients. 7. Immunosuppressive conditions. 8. Patients with other inflammatory diseases.

Design outcomes

Primary

Measure	Time frame	Description
Periodontal Virus and Inflammatory Markers expression in periodontitis patients with coronary artery disease	2 years	Expression of EBV, CMV, HSV, Pentraxins, TLR 2 and TLR 4 using PCR

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026