Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac

Conditions

Breast Cancer, Esophageal Cancer, Head and Neck Cancer, Liver Cancer, Oligometastasis, Prostate Cancer, Rectal Cancer

Keywords

Radiotherapy, Adaptive Radiotherapy

Brief summary

This study investigates the feasibility of imaging and treatment on a novel 1.5 T MR-Linac radiotherapy hybrid device.

Detailed description

Novel hybrid devices combine magnetic resonance imaging (MRI) and a linear accelerator in a single device. The superior soft tissue contrast compared with cone-beam computed tomography based treatment and the possibility for daily plan adaptation promise a higher precision of treatment, better target volume coverage and normal tissue sparing. In a first step the present study will test the feasibility of imaging and treatment on the 1.5 T MR-Linac.

Boeke S, Habrich J, Kübler S, Boldt J, Schick F, Nikolaou K, Kübler J, Gani C, Niyazi M, Zips D, Thorwarth D.

2025-01-292 citations

10.1186/s13014-025-02589-9

Online Adaptive MR-Guided Ultrahypofractionated Radiotherapy of Prostate Cancer on a 1.5 T MR-Linac: Clinical Experience and Prospective Evaluation

Vlatko Potkrajcic, Cihan Gani, Stefan Georg Fischer, Simon Boeke, Maximilian Niyazi et al. (15 authors)

Current Oncology2024-05-095 citations

10.3390/curroncol31050203

First Experience and Prospective Evaluation on Feasibility and Acute Toxicity of Online Adaptive Radiotherapy of the Prostate Bed as Salvage Treatment in Patients with Biochemically Recurrent Prostate Cancer on a 1.5T MR-Linac

Daniel Wegener, Alexandra Thome, Frank Paulsen, Cihan Gani, Jessica Boldt et al. (12 authors)

Journal of Clinical Medicine2022-08-0915 citations

10.3390/jcm11164651

Interventions

RADIATIONRadiotherapy on the MR-Linac

Radiotherapy is performed on the 1.5 T MR Linac

DIAGNOSTIC_TESTImaging on the MR Linac

Only imaging performed on the MR Linac

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* existing indication for radiation therapy * minimum age 18 years, no upper age limit * capacity for consent * Informed consent

Exclusion criteria

* contraindication for MRI (claustrophobia, metallic implants not applicable for MRI * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Feasibility of online MR guided Radiotherapy	During every single patients treatment (i.e. between one to seven weeks after the first application of radiotherapy)	Treatment of a patient is considered feasible when 85% of treatments were completed as planned in this patient

Secondary

Measure	Time frame	Description
Time analysis	During every single patients treatment (i.e. between one to seven weeks after the first application of radiotherapy)	Time required for online MR guided radiotherapy

Countries

Germany

Outcome results

None listed