Sarcopenia
Conditions
Brief summary
Sarcopenia is a pathophysiological process associated with aging and some metabolic conditions characterized by progressive muscle tissue loss, which may lead to loss of strangth and performance and increase risk of falls and fractures, physical disability and premature death. Therefore, it is necessary to identify personalized programs of physical activity and supplementation for elderly population in order to improve their physical functions, muscle strengh and body composition. With the present project we aime to assess the effect of a feasible home-based exercise program coupled with food supplementation to improve muscle strength, muscle volume and muscle physical performance potentially associated with sarcopenia in elderly people.
Interventions
BEHAVIORALPhysical activity
Home-based physical activity program
DIETARY_SUPPLEMENTPhysical activity and supplementation
Home-based physical activity program and amminoacid supplementation
OTHERControl
No intervention
Sponsors
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
60 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Sedentary lifestyle. * Cognitively intact. * Autonomous walking. * Acceptance of informed consent.
Exclusion criteria
* Body mass index lower than 18.5 and uppen than 40 kg/m2. * History of cancer. * Pacemaker user. * History of epileptic episodes. * Endocrine-metabolic, neurological, muscular and ortopedic pathologies that affect movement functions. * Bone fractures that influence movement functions. * Smoking. * Surgical treatments in the prior 6 months. * Use of antieptilectics, glucocorticoids, rhGH and testosterone. * Hepatic and muscular pathologies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lower limb strength | Baseline and Week 24 | Assessed by chair stand test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body composition | Baseline and Week 24 | Assessed by Whole-body dual energy X-ray absorptiometry |
| Quantify thigh cross sectional area | Baseline and Week 24 | Assessed by Dixon magnetic resonance imaging |
| Maximum isometric force that a hand can squeeze | Baseline and Week 24 | Assessed by Hand Grip Strength test |
| Maximal Isometric Strength of Knee flexors and extensors | Baseline AND Week 24 | Assessed by a belt-stabilized dynamometer |
| Dynamic balance and gait deficits | Baseline and Week 24 | Assessed by mini-BESTest |
Countries
Italy
Outcome results
None listed