Sepsis
Conditions
Brief summary
Resuscitation failure, oxidative stress and necroptosis were able to predict mortality in septic patient
Detailed description
This prospective cohort study was conducted at resuscitation room and ICU of Mohammad Hoesin hospital, a single tertiary teaching hospital in Palembang, South Sumatera. This study was started after ethical and location authorization were unleashed in February to August 2019. Inclusion criteria were patients aged 18 years old or above who met Sepsis-3 definition and diagnosed with sepsis. Exclusion criteria were patients whose family did not give any consent to participate, not treated at the ICU, had a late diagnosis (\>24 h), pregnant, and diagnosed with brain dead. Drop out criteria including patients who died \<4 h after diagnosed and could not be followed in 28 days. Investigators were trained to identified all eligible subjects. All the subjects had a standard resuscitation and their blood was taken to be examined at the laboratory. Subjects were observed in 28 days whether there were any mortality or not. Failed resuscitation defined by examined lactate level ≥ 2 mmol/L or lactate reduction \<20%. Data was statistically analyzed with STATA™
Interventions
DIAGNOSTIC_TESTBlood Collection
Blood Gas Analysis using Stat Profile pHOx® Series (nova biomedical, Waltham, U.S.) and Enzym-linked Immunosorbent Assay (ELISA) using Bio-Rad (Bio-Rad Laboratories, California, U.S.)
Sponsors
Indonesia University
Universitas Sriwijaya
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Participants aged 18 years old or above * Diagnosed sepsis using Sepsis-3 definition
Exclusion criteria
* Participants whose family did not give any consent to participate * Not treated at the ICU * Had a late diagnosis (\>24 h) * Pregnant * Brain dead
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Ability of Resuscitation Failure, Protein Carbonyl (PCO) and Receptor Interacting Protein Kinase 3 (RIPK3) for Predicting Mortality in Septic Patients | 28 days | Probability of Mortality in Septic Patients with Resuscitation Failure, High PCO Level and High RIPK3 Level |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| How Sensitive and Specific Protein Carbonyl (PCO) Level for Predicting Mortality in Septic Patients? | 28 days | Sensitivity and Specificity of PCO Level for Predicting Mortality in Septic Patients |
| How Sensitive and Specific Receptor Interacting Protein Kinase 3 (RIPK3) Level for Predicting Mortality in Septic Patients? | 28 days | Sensitivity and Specificity of RIPK3 Level for Predicting Mortality in Septic Patients |
Countries
Indonesia
Outcome results
None listed