The Influence of Sedation for Endoscopy on Cognitive Function

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04168294

Enrollment

200

Registered

2019-11-19

Start date

2019-11-14

Completion date

2019-11-14

Last updated

2019-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognition Disorders, Deep Sedation, Esophagogastroduodenoscopy

Keywords

Esophagogastroduodenoscopy, Deep Sedation, Cognition Disorders, Patient Discharge, Automobile Driving

Brief summary

It is commonly recommended that patients should refrain from driving for 24 hours after sedation for endoscopy，however，this recommendation has been queried recently．To investigate the effect of sedation on early postoperative cognitive function in patients undergoing endoscopy.

Detailed description

One hundred adult patients undergoing sedative esophagogastroduodenoscopy ( EGD) were randomly recruited，and another 100 adult patients undergoing conventional（without sedation） EGD were served as controls． All patients had an education level more than 9 years． Cognitive function was assessed by Montreal Cognitive Assessment（MoCA）1 week before EGD exam, 10 mins before propofol sedation or the beginning of endoscopic procedure, 30mins after EGD exam, and 2 week after exam.

Interventions

DRUGPropofol

patients in sedation group will be intravenous injected propofol in bolus

DEVICEendoscopy

endoscopy system

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 64 Years

Healthy volunteers

Inclusion criteria

1. The scores of MMSE are more than 26. 2. The AHA grade I and II.

Exclusion criteria

1. The AHA grade III, IV or V. 2. binge drinking. 3. Take sedatives, sleeping agents and some drug which may affect the study in a month. 4. Psychiatric disorders. 5. The dysfunction of heart, lung, liver and kidney.

Design outcomes

Primary

Measure	Time frame	Description
DST test outcome measure	30 minutes	the score of DST for each patient is not less than that in the baseline.
number cancellation test outcome measure	30 minutes	the score of number cancellation test for each patient is not less than that in the baseline.
NCT-A test outcome measure	30 minutes	the score of NCT-A test for each patient is not less than that in the baseline.

Secondary

Measure	Time frame	Description
heart rate outcome measure	5 minutes	heart rate less than 50 time per minute
SpO2 outcome measure	5 minutes	SpO2 less than 90%

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026