Hypoxia
Conditions
Keywords
post cardiac surgery,, lung recruitment, trans alveolar pressure
Brief summary
the study is conducted on hypoxic adult patients underwent open heart surgery after arrival to the intensive care unit and stabilization of patients' hemodynamics to assess the efficacy of transalveolar pressure measurement as an index for lung recruitment.
Detailed description
After one hour from the patient's ICU admission and after stabilization of the patient's haemodynamics, alveolar recruitment will be done for hypoxic patients with hypoxic index less than 250. The recruitment will be started in the adaptive ventilation mode (AVM mode) using modified stepwise staircase recruitment maneuver in which every 2 minutes positive end-expiratory pressure (PEEP) is increased in increments of 2 cmH2O and the driving pressure will be regulated by AVM mode. The increase in PEEP will be guided by improvement of dynamic compliance, oxygen saturation and transalveolar pressure (PTA) till near overdistention. Overdistension will be detected if there are decrease in the mean arterial pressure 25% from the base line value reported after stabilization of the patient's haemodynamics, or decreased oxygen saturation or sudden decrease in dynamic compliance, or inspiratory PTA more than15 cm H2O. Then PEEP is decreased 2 cm H2O every 3 minutes till a decrease expiratory PTA less than 1 cm H2O, or a decrease in dynamic compliance or a decrease in oxygen saturation ≥ 1% from maximum oxygen saturation is observed (the derecruitment point) then return to a PEEP level 2 cm H2O above the derecruitment point (the optimal PEEP). Alveolar recruitment will be done once.
Interventions
OTHERlung recruitment protocol
lung recruitment protocol applied to postcardiac surgery hypoxic adult patients with measurement of trans alveolar pressure as an index for lung recruitment
Sponsors
University of Alexandria
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* post cardiac surgery hypoxic adult patients
Exclusion criteria
1. Patients with contraindications for the use of esophageal catheter including esophageal ulcerations, tumors, diverticulitis, bleeding varices, recent esophageal or gastric surgery, sinusitis, epistaxis and recent nasopharyngeal surgery. 2. Postoperative severe haemodynamic instability on high inotropic support. 3. Ejection fraction less than 35%. 4. Severe restrictive or obstructive lung disease. 5. Extremes of age (\<19 and \> 75 years). 6. Morbid obese patients with BMI \> 40kg/m2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| transalveolar pressure | 1 day | cmH2O |
| hypoxic index | 1 day | — |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| dynamic compliance | 1 day | ml/cmH2O |
Countries
Egypt
Outcome results
None listed