Pregnancy Related, Quality of Life, Thyroid Diseases
Conditions
Keywords
quality of life, EQ5D, ThyPRO-39, pregnancy, thyroid disease, thyrotropin, thyroxine, thyroid autoantibodies
Brief summary
Natural thyroid function changes during pregnancy. In up to tens of percent of pregnant women, these changes can lead to pathological fluctuations in hormone and antibody production. Although the effects on pregnancy and child development are well described, none has determined their influence on mother's emotional well-being and the quality of life. At present, universal thyroid screening in pregnancy in the Czech Republic is not covered by health insurance. The aim of the project is to change this situation by providing quality of life estimate for the cost-effectiveness model. This is a project of three specialized institutions aimed at mapping various aspects of the quality of life of pregnant women and describing the impact of thyroid disease on their lives. The project is a parallel study to a larger project Early screening for thyreopathy in pregnancy (CZ.03.2.63/0.0/0.0/15\_039/0009643) supported by the European Fund Operational Programme Employment through the National screening centre. The data will be collected through online questionnaire from women enrolled in the Early screening for thyreopathy in pregnancy (CZ.03.2.63/0.0/0.0/15\_039/0009643) who were screened for TSH, TPOAb and FT4.
Interventions
None listed
Sponsors
Charles University, Czech Republic
Institute of Health Information and Statistics of the Czech Republic
Value Outcomes Ltd.
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Inclusion criteria
* pregnant women * screened for laboratory signs of thyreopathy anytime during pregnancy * willing/able to participate in online survey
Exclusion criteria
* women whose laboratory results were not available or inconclusive * already participated in this survey by filling the online questionnaire * not able to complete the entire questionnaire
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Utility by five-dimensional five-level generic EuroQoL questionnaire (EQ5D 5L) | Immediately after the reception of laboratory results | Health-related quality of life measured as EQ5D 5L questionnaire, score 1 is the best and -0,594 the worst |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thyroid-Related Quality-of-Life Patient-Reported Outcome questionnaire short form (ThyPRO-39) | Immediately after the reception of laboratory results | Health-related quality of life measured as ThyPRO-39 questionnaire, each domain scores between 0 and 100. The higher the score the worse the symptoms. |
Countries
Czechia
Outcome results
None listed