Participants of the Be-MaGIC-Study 2009
Conditions
Keywords
Prolonged exercise, marathon, cardiovascular disease, long term
Brief summary
Pro-MagIC is a prospective observational study and includes participants of the Be-MaGIC-Study 2009 (n=277/NCT00933218). We aim to detect exercise-induced physiological changes (inter alia of the cardiovascular system) induced by repetitive ultra-endurance strain over a period of 10 years.
Detailed description
Physical activity is associated with health benefits. Acute prolonged and strenuous exercise, i.e. Marathon running, leads to hemodynamic, endothelial and myocardial functional changes. Whether these myocardial, endothelial and hemodynamic changes can also develop and persist through repetitive extreme and prolonged physical activity is currently still a matter of controversy. In addition, it is not known whether adaptations and changes over time can develop into clinically relevant cardiovascular events with negative health consequences in healthy athletes. The aim of this study is to detect exercise-induced physiological changes (inter alia of the cardiovascular system) induced by repetitive ultra-endurance strain over a period of 10 years. For this purpose, 277 male participants from the Be-MaGIC study (Marathon 2009) are examined in this prospective observational study. A single examination with the following components will take place: Anthropometry, clinical examination, laboratory, resting / exercise electrocardiography cardiopulmonary stress test, echocardiography, and fundus camera. Further examinations will be conducted in participants with abnormal examination results in line with current clinical recommendations.
Interventions
None listed
Sponsors
Balgrist University Hospital
Deutsches Herzzentrum Muenchen
Technical University of Munich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Declaration of consent Participants must have participated in the Be-MaGIC study in 2009 * current age: 30 - 70 years * sex: male
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of right ventricular systolic function (RV-EF) | 10 years | Echocardiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in left ventricular diastolic function (E/e´) | 10 years | Echocardiography |
| Change in cardiac markers (e.g. cardiac Troponin) | 10 years | Clinical chemistry (blood samples) |
| Change in inflammation markers (e.g. C-reactive Protein) | 10 years | Clinical chemistry (blood samples) |
| Changes in left ventricular ejection fraction (LV-EF) | 10 years | Echocardiography |
| Change in macrocirculation (e.g. Intima media thickness) | 10 years | Carotid sonography |
| Change of prevalence of cardiovascular diseases | 10 years | Questionnaire |
| Association between changes of aforementioned parameters (see Topics 1-8) and potential underlying causes (e.g. sports history like number of ultraendurance competitions) in the examined cohort | 10 years | — |
| Change in microcirculation (e.g. arteriolar-to-venular ratio) | 10 years | Static Retinal Vessel Analyzer |
Countries
Germany
Outcome results
None listed