Cystic Fibrosis
Conditions
Keywords
resveratrol, nicotinamide riboside, exercise intolerance
Brief summary
The purpose of this research study is to examine if the use of antioxidant supplements impacts exercise intolerance in people with CF.
Detailed description
Exercise intolerance is a critical problem for people with cystic fibrosis (CF) able to predict hospitalization independent of lung function. Recent studies have suggested that certain supplements may help improving exercise intolerance.
Interventions
Sponsors
Virginia Commonwealth University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
CF * Diagnosis of CF * Men and women (\> 18 yrs. old) * FEV1 percent predicted \> 40% * Patients with or without CF related diabetes * Resting oxygen saturation (room air) \>90% * Traditional CF-antioxidant medications * Ability to perform reliable/reproducible PFTs * Clinically stable for 4 weeks (no exacerbations or need for antibiotic antioxidant within 4 weeks of testing or major change in medical status) * Pancreatic sufficient and pancreatic insufficient patients
Exclusion criteria
CF * Children 17 years old and younger * FEV1\<40% predicted * Resting O2 saturation \<90% * Clinical diagnosis of heart disease * Clinical diagnosis of PAH * Febrile illness within 4 weeks of a study visit * Antioxidant for pulmonary exacerbation within 4 weeks of a study visit * Currently smoking, pregnant or nursing * Vasoactive medications (i.e. nitrates, beta-blockers, Viagra etc.) * Patients with B. Cepacia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Sirtuin1 (Sirt1) | Change from baseline to up to 20 weeks | Sirt1 will be assessed via a standard assay from samples taken from the participant's vein |
Countries
United States
Outcome results
None listed