Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary
Conditions
Brief summary
Fluorescence-navigated thoracoscopic imaging with indocyanine green (ICG) is a novel technique for detection of small pulmonary nodules other than traditional radiography or intraoperative palpation. As a non-targeted fluorescent contrast agent, ICG accumulates in tumors by the enhanced permeability and retention effect (EPR), making the lesions fluoresce under fluorescent imaging. However, the optimal dosage and injection time of ICG are still under exploration. Hence, we perform this study in humans made up of four groups to determine the optimal time and dose.
Interventions
PROCEDUREPreoperative Infusion of Indocyanine Green
preoperatively infuse indocyanine green through peripheral vein
Sponsors
Peking University People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Peripheral pulmonary solid nodules, with diameter 1-3 cm. * Suitable for surgery and signed informed consent.
Exclusion criteria
* Liver dysfunction. * Allergic to indocyanine green. * Can't tolerate thoracoscopic surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Signal-to-background Ratio (SBR) of the Tumor and Normal Parenchyma | within 1 week after surgery | We use image analysis software ImageJ to evaluate the strength of luminosity in tumors and normal parenchyma using intraoperative images and calculate signal-to-background-ratios. |
Countries
China
Contacts
Primary ContactFeng Yang, MD
Backup ContactTiezheng Li, MD
Outcome results
None listed