Lung Transplant; Complications
Conditions
Brief summary
The investigators hypothesis is that an injection into the inferior vena cava associated with a provocation maneuver should allow to increase the incidence of FOP found by transesophageal echocardiography in a population of patients undergoing lung transplantation.
Interventions
DIAGNOSTIC_TESTsearch for a patent foramen ovale
Injection of a contrast solution A - In the upper cellar territory with controlled ventilation without positive tele-expiratory pressure; B - In the upper cellar territory in controlled ventilation with a positive end-to-expiratory pressure of 10cm H2O; C - In the lower cellar territory with controlled ventilation without positive tele-expiratory pressure; D - In the lower cellar territory in controlled ventilation with a positive end-to-expiratory pressure of 10cm H2O;
Sponsors
Hopital Foch
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Intervention model description
For each patient the 4 tests will be performed in a randomized order to limit bias
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged 18 years old minimum * Benefiting from a lung transplant * Having an upper vena cava catheter and a lower vena cava catheter set up as part of the usual care * Having signed a consent form * Affiliated to a insurance scheme or beneficiary (excluding AME)
Exclusion criteria
* Pregnant or lactating women * Having a contraindication to the insertion of the esophageal ultrasound probe * deprived of liberty or under guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of transatrial passage of contrast media | 1 day after lung transplantation | Incidence of transatrial passage of contrast media |
Secondary
| Measure | Time frame |
|---|---|
| Number of postoperative days with mechanical ventilation | 30 days after lung transplantation |
| Incidence of pulmonary graft dysfunction, incidence of stroke, incidence of myocardial ischemia | 30 days after lung transplantation |
| Size of PFO, existence of an atrial septal aneurysm | 1 day after lung transplantation |
| Mortality during the stay in the hospital | 30 days after lung transplantation |
| Mortality at the postoperative 30-day | 30 days after lung transplantation |
| Mortality during the stay in the intensive care unit | 30 days after lung transplantation |
Countries
France
Outcome results
None listed