Disorder of Consciousness, FDG-PET, Minimally Conscious State, Rs-fMRI
Conditions
Keywords
Disorder of Consciousness, Unresponsive wakefulness syndrome, Multimodal Neuroimaging
Brief summary
Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.
Interventions
DIAGNOSTIC_TESTMultimodal Neuroimaging
fludeoxyglucose (FDG-)PET/MR imaging
Sponsors
Hangzhou Normal University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* DOC patients （acute, subacute or chronic period）: Coma, UWS and MCS.
Exclusion criteria
* neuromuscular blocking agents or sedative drugs administered within the prior 24 hours； * unstable medical condition； * mental implant in the brain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| resting-state fMRI | Within 7 days | Use resting-state fMRI to test the functional connectivity |
| fludeoxyglucose (FDG-)PET | Within 7 days | UseFDG-PET to test the metabolism. |
Countries
China
Outcome results
None listed