Acute Kidney Injury, Angina, Stable, Angina, Unstable, Contrast-induced Nephropathy, Coronary Artery Disease, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction
Conditions
Keywords
coronary artery disease, iodinated contrast media, stable angina, unstable angina, STEMI, NSTEMI, PCI, acute kidney injury
Brief summary
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors of contrast-induced acute kidney injury development and the influence of contrast-induced kidney injury on 1-year prognosis.
Interventions
OTHERIodinated contrast
Intra-arterial injection of iodinated contrast media during percutaneous coronary intervention
Sponsors
I.M. Sechenov First Moscow State Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* Males and females aged 18-80 * Stable CAD receiving optimal medical treatment requiring PCI or STEMI or NSTEMI * Intra-arterial injection of iodinated contrast media * Informed consent
Exclusion criteria
* Age less than 18 * Pregnancy, lactation * Refuse to sign the informed consent * Contraindications for PCI * Other conditions affecting prognosis (oncology, liver failure etc) * CKD stage 4-5 * Patients receiving nephrotoxic drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Contrast associated acute kidney injury | 48-72 hours | Number of patients with contrast associated kidney injury after contrast exposure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall mortality | 1 year | — |
| Cardiovascular mortality | 1 year | — |
| Myocardial infarction | 1 year | Number of patients with myocardial infarction |
| Stroke | 1 year | — |
| Acute decompensation of heart failure | 1 year | Number of patients with acute decompensation of heart failure |
| Repeat hospitalisation | 1 year | — |
| Chronic kidney disease progression | 1 year | Progression of chronic kidney disease in patients with decreased glomerular filtration rate on inclusion |
| New-onset dialysis | 1 year | Number of patients with new-onset dialysis |
| Repeat revascularization | 1 year | PCI or CABG |
Countries
Russia
Outcome results
None listed