Tumor, Brain
Conditions
Brief summary
In this pilot study, the investigators propose a multimodal evaluation of the brain connectivity of brain tumor patients, in order to better understand the effects induced by focal lesions on brain structure and function, as well as brain plasticity mechanisms that may occur in such condition. The investigators aim at drawing a multimodal brain connectivity map of focally brain-damaged patients, with a view to improve onco-functional neurosurgical practices.
Detailed description
Patients included in the present study will first perform the pre-operative MRI (dMRI and fMRI) with a specific High Resolution Angular Diffusion (HARDI) sequence and a functional acquisition at rest. Then, the investigators will record their cortico-cortical evoked potentials elicited by direct electrostimulation during the surgery, just before the tumor removal, following our usual protocol. Finally, all data (clinical, diffusion, electrical and functional connectivity) will be processed and correlated to each other.
Interventions
OTHERdMRI, fMRI and electrocorticography
Patients included in the study will perform the pre-operative MRI (fMRI and fMRI) with a specific High Resolution Angular Diffusion (HARDI) sequence and a functional rest sequence. The additional scan time for this specific sequence is approximately 25 minutes, with no foreseeable negative impact on the patient
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients with brain tumor for removal * Age \> 18 years * Informed patient consent * Membership of social security scheme
Exclusion criteria
* Contraindication to MRI * Any subject with vascular stent implanted less than 6 weeks prior to the exam; * Any subject carrying an intraocular or intracranial ferromagnetic foreign object close to nerve structures; * Any subject carrying biomedical equipment such as a cardiac, neuronal or sensory pacemaker (cochlear implant) or a ventricular bypass valve without medical and paramedical supervision trained in the performance of MRI in these subjects; * Presence of more than one brain tumor * Refusal of patient participation * Pregnant or nursing women. A urinary pregnancy test will be conducted for women of childbearing age. The results will be communicated to the patient by a doctor of her choice. * Person staying in a health or social establishment * Person in emergency situation * Vulnerable patient: deprived of liberty, guardianship, curators, or safeguarding of justice
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlations between tumor topography, cortical electrical conduction rates measured in electrocorticography, and microstructural measurements of white substance from diffusion MRI | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Correlations between neurological disorders, tumor topography and network disruption identified in functional rest MRI | 1 month |
Countries
France
Outcome results
None listed