Kidney Cancer
Conditions
Brief summary
The purpose of this study is to evaluate the effect of papaverine on renal artery blood flow after declamping of renal artery.
Detailed description
The purpose of this study is to evaluate the effect of papaverine on renal artery blood flow after declamping of renal artery in patients undergoing robot assisted partial nephrectomy.
Interventions
DRUGPapaverine
Immediately after the renal artery declamping, papaverine 30 mg (1 ample, 1 ml) is mixed with 5 ml of normal saline (total 6 ml) and sprinkled around the renal artery.
DRUGNormal saline
Immediately after the renal artery declamping, normal saline 6 ml is sprinkled around the renal artery.
Sponsors
Asan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with kidney cancer. * Patients undergoing robot assisted partial nephrectomy under general anesthesia * 20 years old ≤ age \<80 years old * Patients who voluntarily agreed to this clinical study * eGFR ≥ 60 ml / min / 1.73 m2 (Chronic Kidney Disease Epidemiology Patients with Collaboration)
Exclusion criteria
* The tumor ≥ 7 cm in size * Multiple renal mass * If the surgery plan is changed due to open * When surgery is performed together with other surgery * Multiple renal artery * Patients with hypersensitivity to papaverine * Patients with atrioventricular block * Pregnant and lactating women * Patients using levodopa * Refusal of patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Renal artery blood flow | at 2 minutes after papaverine administration | Renal artery blood flow 2 minutes after papaverine administration by doppler sonography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| estimated glomerular filtration rate | at postoperative day 0 | estimated glomerular filtration rate using KIDGO equation |
| glomerular filtration rate using renal scan | at postoperative month 3 | glomerular filtration rate using renal scan |
Countries
South Korea
Outcome results
None listed