Thymoma
Conditions
Brief summary
The purpose of this study is to understand how genetics play a role in thymoma. Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. This study aims to find out how it affects genetic and protein expression in patients with malignant thymoma, compared to Benign thymoma, at a single-cell level using a flow cytometry and RNA-sequencing protocol.
Interventions
DIAGNOSTIC_TESTTissue
Four 4-5 mm tissues of the thymoma
Sponsors
Zhejiang Cancer Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients diagnosed with thymoma * Ability to provide written consent and comply with the protocol * At least 18 years of age
Exclusion criteria
* Patients undergoing thymoma treatment * Patients with previous malignancy * Known HIV positive status. * Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination of cell population from thymoma | through study completion, an average of 1 year | The genes expression and the cell population |
Countries
China
Contacts
Primary ContactAn ZHAO, MD, PHD
Outcome results
None listed