Anterior Cruciate Ligament Injuries
Conditions
Keywords
anterior cruciate ligament injury, re-injury, muscle function, functional performance, rehabilitation, physiotherapy, sensorimotor control
Brief summary
In this longitudinal prospective cohort study including young people with anterior cruciate ligament (ACL) reconstruction, the investigators will evaluate if poor sensorimotor function at baseline can predict 1) graft rupture 2) the risk of contra-lateral ACL injury and 3) failure to return to sport/previous activity level within 3 years following ACL reconstruction.
Detailed description
In this longitudinal prospective cohort study including young athletic men and women (aged 15-35) with ACL reconstruction (ACLR), it will be investigated if poor sensorimotor function at baseline (1 year post ACLR), such as hop performance, muscle strength and postural orientation can predict 1) graft rupture 2) the risk of contra-lateral ACL injury and 3) failure to return to sport/previous activity level within 3 years following ACLR. Statistics Separate logistic regression models will be used to elucidate the influence of each muscle sensorimotor function variable on the outcomes (graft rupture, contra-lateral injury, return to sport/activity level failure), adjusted for potential confounders. With the LSI for the single-leg hop test as main outcome, power calculations show that with a re-injury rate of 7%, an estimated odds ratio of 0.95, power=80% and alpha=5 %, at least 174 individuals are needed. Based on this calculation, 200 individuals will be included for the prospective analysis, allowing for an approximate drop-out of 10%.
Interventions
OTHERDifferent measures of muscle function such as muscle strength, hop tests, postural orientation and muscle activation
The participants will be assessed with a physical test battery at baseline including: Isokinetic knee strength, Isometric strength of trunk and lower extremity, Single-leg hop for distance, side hop, postural orientation (single leg-squat, stair descending, forward lunge, Single-leg hop for distance, side-hop), hip and ankle range of joint motion, muscular activation pattern, 3D movement analysis and proprioception test. At follow-up (2 years), the participants will be asked to answer a survey about new ACL injuries and return to sport/previous activity level.
Sponsors
Umeå University
Lund University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* 8-16 months after ACL reconstruction * With or without associated injuries to other structures of the knee (e.g., collateral ligament(s), meniscal injury) * Age 15-35 years.
Exclusion criteria
* ACL injury other knee and previous ACL injury index knee * Diseases or disorders overriding the knee condition (e.g., neurological or rheumatological disease) * Not understanding the languages of interest (any Scandinavian language or English).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with graft rupture | 2 years | Number of patients that have sustained a rupture of the reconstructed ligament |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with contra-lateral ACL injury | 2 years | Number of patients that have sustained an injur to the contra-lateral knee |
| Failure to return to sport/previous activity level | 2 years | Number of patients that had failed to return to previous sport/activity level |
Countries
Sweden
Contacts
PRINCIPAL_INVESTIGATORAnna Cronström, PhD
Umeå University
STUDY_CHAIRCharlotte Häger, Professor
Umeå University
Outcome results
None listed