Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children

Comparison of Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With Cystic Fibrosis, Primary Ciliary Dyskinesia and Healthy Children

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04161313

Enrollment

Registered

2019-11-13

Start date

2019-12-20

Completion date

2020-03-12

Last updated

2020-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cystic Fibrosis, Primary Ciliary Dyskinesia

Keywords

respiratory functions, exercise capacity, muscle strength

Brief summary

The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.

Detailed description

The impaired airway clearence and pulmonary functions, exercise intolerance, low physical activity level and decreased peripheral muscle strength make physiotherapy approaches important in the management of CF and PCD.

Interventions

OTHERMeasurement of functional capacity

Functional capacity of participants will be measured with six-minute walk test.

OTHERpulmonary function test

It will be measured using basic spirometry and presented lung volume parameters such as FEV1,FVC,FEV1/FVC,PEF, FEF25-75

OTHERFunctional capacity

Functional capacity of participants will be measured with six-minute walk test and sit-to-stand test

OTHERPeripheral muscle strength

Isometric M. Quadriceps strength will be measured using electronic hand held dynamometer in sitting position.

OTHERRespiratory muscle strength

Inspiratory and expiratory muscle strength has been assessed by maximal inspiratory and expiratory mouth pressures.

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Diagnosis of cystic fibrosis or primary ciliary dyskinesia

Exclusion criteria

* Hospitalization history in past month * Diagnosis of other chronic pediatric diseases which may impair exercise tolerance such as cerebral palsy or neuromuscular disease * Candidates for lung transplantation or history of lung transplantation

Design outcomes

Primary

Measure	Time frame	Description
Six-minute walk test distance	15 minutes	Distance walked in six minutes will be recorded in meters. Test will be conducted according to the guideline of American Thoracic Society (ATS).

Secondary

Measure	Time frame	Description
Forced Vital Capacity (FVC)	5 minutes	FVC will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)
Forced Expiratory Volume in 1 second (FEV1)	5 minutes	FEV1 will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)
Peak Expiratory Flow (PEF)	5 minutes	PEF will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)
M. Quadriceps strength	5 minutes	Isometric M. Quadriceps strength (kg) will be measured using electronic hand held dynamometer in sitting position.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026