Skip to content

Persuasion in Medicine: Experimental Evidence on Sender and Signal Effects

Persuasion in Medicine: Experimental Evidence on Sender and Signal Effects

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04160975
Enrollment
3245
Registered
2019-11-13
Start date
2019-12-20
Completion date
2021-02-19
Last updated
2021-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid19, Flu, Human, Influenza, Human

Keywords

Belief Updating, Preventive Care, Racial Disparity

Brief summary

The aim of the study is to identify what sender/signal combinations are most persuasive in encouraging low socioeconomic males living in the U.S. to take-up seasonal flu vaccination. The investigators plan to recruit male subjects and randomly assign them to four persuasion treatments: three of which vary dimensions of the sender of a medical recommendation (racial concordance and authority treatments) and one which varies the signal (standard vs. empathetic). Specifically, the investigators will show subjects videos of either Black or white actors/actresses providing scripted information on the flu vaccination. The investigators will randomize the race of the sender and if the subject is Black, also randomize the authority of the sender, with the actor portraying either a doctor or a layperson. In addition, the investigators will vary the script used in the experiment between one that acknowledges past injustices (indicated as an empathetic script hereafter) and one that does not (indicated as a standard script hereafter). The investigators will provide subjects a free flu shot coupon and elicit the price at which subjects would be willing to give up this coupon for a cash reward. Lastly, in light of the relevance of vaccination take-up in combating COVID-19 pandemic, the investigators will assess demand for information about a COVID-19 vaccine, with subjects invited to receive results of a safety and efficacy review from a trusted or standard source. The design requires the collection of baseline and endline surveys combined with administrative data from pharmacies about coupon redemption. The primary outcomes of interest are posterior beliefs about seasonal flu vaccination, demand and willingness-to-pay (WTP) for a free flu shot coupon, redemption of the coupon, and demand for information about a COVID-19 vaccine.

Detailed description

The investigators will recruit approximately 3350 African-American or Caucasian adult males with a high-school diploma or less. A pilot study, which ran during the 2019-20 flu season, recruited approximately 850 subjects, and a planned scale-up will recruit an additional 2500 subjects during the 2020-21 flu season. The investigators will oversample African American individuals, emphasizing low-income and minority men because these characteristics are correlated with lower relative take-up of flu vaccination. After informed consent is obtained, subjects will be asked about sociodemographic information (age, education, income and marital status), healthcare experience and past medical history, knowledge and beliefs about flu vaccination, and location of the nearest pharmacy. The investigators will then randomly assign the adult male subjects to videos which contain one of Black or white actors playing the role of either a doctor or a layperson as well as different scripts. The content of the infomercial will be the safety and effectiveness of adult seasonal flu vaccination. After the video, the investigators will obtain information on beliefs regarding vaccination, feedback on the video, attention to the video and willingness-to-pay for a flu shot coupon. The final baseline module will consist of a randomly assigned invitation to receive the results of an upcoming review of a COVID-19 vaccine, with subjects assigned to receive information from a trusted or standard source. The investigators will track flu coupon redemption, which is redeemable at most pharmacies nationwide.

Interventions

BEHAVIORALVideo about safety and effectiveness of adult seasonal flu vaccination

The investigators will show subjects videos of either Black or white male actors providing scripted information on the flu vaccination. The content of the video will be the safety and effectiveness of adult seasonal flu vaccination. The videos contain one of Black or white actors playing the role of either a doctor or a layperson as well as different scripts.

Sponsors

Ludwig-Maximilians - University of Munich
CollaboratorOTHER
Massachusetts Institute of Technology
CollaboratorOTHER
National Institute on Aging (NIA)
CollaboratorNIH
Harvard University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
MALE
Age
18 Years to 51 Years
Healthy volunteers
Yes

Inclusion criteria

* Age: See above. * Education: Less than a college degree. * Gender: Male. * Race: Caucasian or African American. * Miscellaneous: Has not received the flu shot in the current flu season yet. * Miscellaneous: Has sound on his device turned on.

Exclusion criteria

* Fast survey-taking: subjects who are among the 5% fastest in terms of total time spent on survey within race and treatment group. * Nonsense answers (those that do not have decipherable English) in the open text sections that suggest low effort. * Inconsistent responses to questions (such as being willing to give up $10 to receive a flu coupon but not $1). * Repeat survey takers as indicated by duplicate emails or IP addresses in survey data.

Design outcomes

Primary

MeasureTime frameDescription
Rating of SenderThis outcome was assessed during Baseline survey, which took approximately 20 minutes.This is an inverse-covariance-weighted index comprised of responses to survey questions regarding: 1. whether the respondent was interested in further medical advice from the given sender (measured as a binary outcome); 2. whether the respondent trusted advice from the sender measured on a scale of 1 to 5; 3. and whether the respondent's assessment of the sender's qualification to provide medical advice measured on a scale of 1 to 5. It is standardized to a mean of 0 and standard deviation of 1. Scores less than 0 indicate lower ratings of the sender rated by participants in Arm A (described in each arm/group description) compared to the rating rated by participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate higher ratings of the sender by Arm A compared to by Arm B. For example, an index score of .18 indicates that participants in Arm A rate the sender 0.18 index (in standard deviation units) higher than those in Arm B.
Rating of SignalThis outcome was assessed during Baseline survey, which took approximately 20 minutes.This is an inverse-covariance-weighted index comprised of responses to survey questions on: 1. recommending the video to friends and family measured on a scale of 0 to 10; 2. recommending the flu shot to friends and family measured on a scale of 0 to 10; 3. and the respondent's assessment of the extent to which the information contained in the video was useful measured on a scale of 1 to 5. It is standardized to a mean of 0 and standard deviation of 1. An index score of 0 is equal to the mean. Scores less than 0 indicate lower ratings of the signal rated by participants in Arm A (described in each arm/group description) compared to the rating rated by participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate higher ratings of the signal by Arm A compared to by Arm B. For example, an index score of 0.14 indicates that participants in Arm A rate the signal 0.14 index (in standard deviation units) higher than those in Arm B.
Signal Content RecallThis outcome will be assessed during Baseline survey, which takes approximately 20 minutes.This is an inverse-covariance-weighted index comprised of responses to survey questions on: 1. whether age group for whom the flu vaccine is recommended (measured as a binary outcome); and 2. whether the flu shot contains the flu virus (recall of information discussed in the video) (measured as a binary outcome). It is standardized to a mean of 0 and standard deviation of 1. An index score of 0 is equal to the mean. Scores less than 0 indicate lower level of recalling signal content among participants in Arm A (described in each arm/group description) compared to the level among participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate a higher level of recalling signal content among participants in Arm A compared to those in Arm B. For example, an index score of 0.02 indicates that participants in Arm A recall signal content 0.02 index (in standard deviation units) higher than those in Arm B.
Safety BeliefsThis outcome will be assessed during Baseline survey, which takes approximately 20 minutes.This is an inverse-covariance-weighted index comprised of: 1. the point belief on the likelihood to contract the flu from the flu shot measured by a Likert scale and rescaled to have a support of -1 to 1. 2. the certainty measured with a balls and bins method and rescaled to have a support of -1 to 1. It is standardized to a mean of 0 and standard deviation of 1. An index score of 0 is equal to the mean. Scores less than 0 indicate a lower level of beliefs in the safety of flu vaccine among participants in Arm A (described in each arm/group description) compared to the level among participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate a higher level of beliefs among participants in Arm A compared to those in Arm B. For example, an index score of -0.1 indicates that participants in Arm A hold such beliefs 0.1 index (in standard deviation units) lower than those in Arm B.
Coupon InterestThis outcome was assessed during Baseline survey, which took approximately 20 minutes.This is an inverse-covariance-weighted index comprised of revealed preference measures of demand for a free flu shot coupon: 1. Willingness to pay (WTP) for the coupon measured as $0, $1, $2, $5, or $10 2. demand for information regarding locations to redeem the coupon measured as a binary outcome It is standardized to a mean of 0 and standard deviation of 1. An index score of 0 is equal to the mean. Scores less than 0 indicate a lower level of interest in a free flu shot coupon distributed after survey completion among participants in Arm A (described in each arm/group description) compared to the level among participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate a higher level of interest among participants in Arm A compared to those in Arm B. For example, an index score of -0.01 indicates that participants in Arm A hold such interest -0.01 index (in standard deviation units) higher than those in Arm B.
(Posterior) Flu Vaccine IntentThis outcome was assessed after the video treatment during Baseline survey, which took approximately 20 minutes.This is the respondent's likelihood to receive the flu vaccine before the end of the flu season. This was elicited on an 11-point Likert scale (0 extremely unwilling, 10 extremely willing) after the video message treatment. We re-scaled this outcome to have a scale of 0 to 1. The reported results of the outcome compare participants in Arm A and Arm B (described in each arm/group description). For example, an intent of 0.03 indicates that participants in Arm A are 0.03 units on a scale more likely to intent to take up the flu vaccine compared to those in Arm B.
COVID-19 Vaccine IntentThis outcome was assessed after the video treatment during Baseline survey, which took approximately 20 minutes.This is the respondent's likelihood to take up the COVID-19 vaccine if made available free of charge. This was elicited on an 11-point Likert scale (0 extremely unwilling, 10 extremely willing) after the video message treatment. We re-scaled this outcome to have a scale of 0 to 1. The reported results of the outcome compare participants in Arm A and Arm B (described in each arm/group description). For example, an intent of 0.04 indicates that participants in Arm A are 0.04 units on a scale more likely to intent to take up the COVID-19 vaccine compared to those in Arm B.
Flu Vaccine Take-upThis outcome was assessed during the follow-up survey which was conducted at least two weeks after the initial baseline survey.This is respondents' self-report in the follow-up survey on whether they or their family members had received the flu shot or redeemed the coupon since the intervention. The reported results of the outcome compare participants in Arm A and Arm B (described in each arm/group description). For example, 15.0 percentage points indicate that participants in Arm A are more likely to report that they and/or another household member received the flu vaccine by 15.p percentage points compared to those in Arm B.

Countries

United States

Participant flow

Participants by arm

ArmCount
Black Participant-Concordant Sender-Expert Sender-Standard Signal
Black participants who are assigned to a concordant-exper sender delivering a standard signal.
415
Black Participant-Concordant Sender-Lay Sender-Standard Signal
Black participants who are assigned to a concordant-lay sender delivering a standard signal.
430
Black Participant-Discordant Sender-Expert Sender-Standard Signal
Black participants who are assigned to a discordant-exper sender delivering a standard signal.
417
Black Participant-Discordant Sender-Expert Sender-Acknowledgement Signal
Black participants who are assigned to a discordant-exper sender delivering a acknowledgement signal.
410
White Participant-Concordant Sender-Expert Sender-Standard Signal
White participants who are assigned to a concordant-exper sender delivering a standard signal.
614
White Participant-Discordant Sender-Expert Sender-Standard Signal
White participants who are assigned to a discordant-exper sender delivering a standard signal.
607
Total2,893

Baseline characteristics

CharacteristicBlack Participant-Concordant Sender-Lay Sender-Standard SignalBlack Participant-Concordant Sender-Expert Sender-Standard SignalTotalWhite Participant-Discordant Sender-Expert Sender-Standard SignalWhite Participant-Concordant Sender-Expert Sender-Standard SignalBlack Participant-Discordant Sender-Expert Sender-Acknowledgement SignalBlack Participant-Discordant Sender-Expert Sender-Standard Signal
Age, Continuous35.53023 years
STANDARD_DEVIATION 6.219959
35.92048 years
STANDARD_DEVIATION 6.717987
36.82613 years
STANDARD_DEVIATION 6.742281
38.16474 years
STANDARD_DEVIATION 6.760583
38.11401 years
STANDARD_DEVIATION 6.773668
35.90488 years
STANDARD_DEVIATION 6.857133
36.1247 years
STANDARD_DEVIATION 6.46877
Has Primary Care Provider178 Participants189 Participants1374 Participants323 Participants321 Participants171 Participants192 Participants
High School
Completed
380 Participants359 Participants2555 Participants533 Participants554 Participants355 Participants374 Participants
High School
Not completed
50 Participants56 Participants338 Participants74 Participants60 Participants55 Participants43 Participants
Insured251 Participants234 Participants1763 Participants391 Participants403 Participants239 Participants245 Participants
Married86 Participants71 Participants711 Participants186 Participants202 Participants77 Participants89 Participants
(Prior) Flu Vaccine Intent2.786047 units on a scale
STANDARD_DEVIATION 3.324808
2.554217 units on a scale
STANDARD_DEVIATION 3.243176
2.566886 units on a scale
STANDARD_DEVIATION 3.228842
2.52883 units on a scale
STANDARD_DEVIATION 3.237376
2.596091 units on a scale
STANDARD_DEVIATION 3.146201
2.485366 units on a scale
STANDARD_DEVIATION 3.147713
2.446043 units on a scale
STANDARD_DEVIATION 3.307566
(Prior) Likelihood of Contracting Flu2.072093 units on a scale
STANDARD_DEVIATION 2.791414
2.342169 units on a scale
STANDARD_DEVIATION 2.853683
2.476668 units on a scale
STANDARD_DEVIATION 2.774967
2.912685 units on a scale
STANDARD_DEVIATION 2.701415
2.760586 units on a scale
STANDARD_DEVIATION 2.603112
2.304878 units on a scale
STANDARD_DEVIATION 2.86659
2.143885 units on a scale
STANDARD_DEVIATION 2.823905
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Asian
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Black or African American
430 Participants415 Participants1672 Participants0 Participants0 Participants410 Participants417 Participants
Race (NIH/OMB)
More than one race
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
Unknown or Not Reported
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Race (NIH/OMB)
White
0 Participants0 Participants1221 Participants607 Participants614 Participants0 Participants0 Participants
Region of Enrollment
United States
430 participants415 participants2893 participants607 participants614 participants410 participants417 participants
Sex: Female, Male
Female
0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants0 Participants
Sex: Female, Male
Male
430 Participants415 Participants2893 Participants607 Participants614 Participants410 Participants417 Participants
Subjective Flu Shot Cost42.74393 dollar
STANDARD_DEVIATION 85.77928
43.91588 dollar
STANDARD_DEVIATION 91.2157
33.56405 dollar
STANDARD_DEVIATION 70.94346
25.02221 dollar
STANDARD_DEVIATION 48.44235
25.28546 dollar
STANDARD_DEVIATION 50.80593
33.8441 dollar
STANDARD_DEVIATION 72.69948
38.14388 dollar
STANDARD_DEVIATION 79.24301
Subjective Health Status3.751163 units on a scale
STANDARD_DEVIATION 1.003925
3.522892 units on a scale
STANDARD_DEVIATION 1.009056
3.468372 units on a scale
STANDARD_DEVIATION 1.030375
3.237232 units on a scale
STANDARD_DEVIATION 0.9965605
3.21987 units on a scale
STANDARD_DEVIATION 0.992071
3.653659 units on a scale
STANDARD_DEVIATION 1.056843
3.642686 units on a scale
STANDARD_DEVIATION 1.0069

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
EG002
affected / at risk
EG003
affected / at risk
EG004
affected / at risk
EG005
affected / at risk
deaths
Total, all-cause mortality
0 / 4790 / 4960 / 4780 / 4850 / 6490 / 658
other
Total, other adverse events
0 / 4790 / 4960 / 4780 / 4850 / 6490 / 658
serious
Total, serious adverse events
0 / 4790 / 4960 / 4780 / 4850 / 6490 / 658

Outcome results

Primary

Coupon Interest

This is an inverse-covariance-weighted index comprised of revealed preference measures of demand for a free flu shot coupon: 1. Willingness to pay (WTP) for the coupon measured as $0, $1, $2, $5, or $10 2. demand for information regarding locations to redeem the coupon measured as a binary outcome It is standardized to a mean of 0 and standard deviation of 1. An index score of 0 is equal to the mean. Scores less than 0 indicate a lower level of interest in a free flu shot coupon distributed after survey completion among participants in Arm A (described in each arm/group description) compared to the level among participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate a higher level of interest among participants in Arm A compared to those in Arm B. For example, an index score of -0.01 indicates that participants in Arm A hold such interest -0.01 index (in standard deviation units) higher than those in Arm B.

Time frame: This outcome was assessed during Baseline survey, which took approximately 20 minutes.

Population: Arms/Groups are combined as described in each arm/group description in order to test hypotheses prespecified in the analysis plan as well as to measure the effect of the given intervention on the outcome among the group of participants in Arm A compared to Arm B. The intervention and Arms A and B are described in each arm/group description.

ArmMeasureValue (NUMBER)
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - Black ParticipantsCoupon Interest-.0078177 index
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - White ParticipantsCoupon Interest-.0827849 index
Acknowledgement (Arm A) vs. Standard Signal (Arm B) - Black ParticipantsCoupon Interest.0280955 index
Layperson Sender (Arm A) vs. Expert Sender (Arm B) - Black ParticipantsCoupon Interest-.0162865 index
Primary

COVID-19 Vaccine Intent

This is the respondent's likelihood to take up the COVID-19 vaccine if made available free of charge. This was elicited on an 11-point Likert scale (0 extremely unwilling, 10 extremely willing) after the video message treatment. We re-scaled this outcome to have a scale of 0 to 1. The reported results of the outcome compare participants in Arm A and Arm B (described in each arm/group description). For example, an intent of 0.04 indicates that participants in Arm A are 0.04 units on a scale more likely to intent to take up the COVID-19 vaccine compared to those in Arm B.

Time frame: This outcome was assessed after the video treatment during Baseline survey, which took approximately 20 minutes.

Population: Arms/Groups are combined as described in each arm/group description in order to test hypotheses prespecified in the analysis plan as well as to measure the effect of the given intervention on the outcome among the group of participants in Arm A compared to Arm B. The intervention and Arms A and B are described in each arm/group description.

ArmMeasureValue (NUMBER)
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - Black ParticipantsCOVID-19 Vaccine Intent.0350147 units on a scale
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - White ParticipantsCOVID-19 Vaccine Intent.009072 units on a scale
Acknowledgement (Arm A) vs. Standard Signal (Arm B) - Black ParticipantsCOVID-19 Vaccine Intent.0544277 units on a scale
Layperson Sender (Arm A) vs. Expert Sender (Arm B) - Black ParticipantsCOVID-19 Vaccine Intent.0881949 units on a scale
Primary

Flu Vaccine Take-up

This is respondents' self-report in the follow-up survey on whether they or their family members had received the flu shot or redeemed the coupon since the intervention. The reported results of the outcome compare participants in Arm A and Arm B (described in each arm/group description). For example, 15.0 percentage points indicate that participants in Arm A are more likely to report that they and/or another household member received the flu vaccine by 15.p percentage points compared to those in Arm B.

Time frame: This outcome was assessed during the follow-up survey which was conducted at least two weeks after the initial baseline survey.

Population: Arms/Groups are combined as described in each arm/group description in order to test hypotheses prespecified in the analysis plan as well as to measure the effect of the given intervention on the outcome among the group of participants in Arm A compared to Arm B. The intervention and Arms A and B are described in each arm/group description.

ArmMeasureValue (NUMBER)
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - Black ParticipantsFlu Vaccine Take-up-7.70997 percentage points
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - White ParticipantsFlu Vaccine Take-up-01.39307 percentage points
Acknowledgement (Arm A) vs. Standard Signal (Arm B) - Black ParticipantsFlu Vaccine Take-up-12.00413 percentage points
Layperson Sender (Arm A) vs. Expert Sender (Arm B) - Black ParticipantsFlu Vaccine Take-up14.96955 percentage points
Primary

(Posterior) Flu Vaccine Intent

This is the respondent's likelihood to receive the flu vaccine before the end of the flu season. This was elicited on an 11-point Likert scale (0 extremely unwilling, 10 extremely willing) after the video message treatment. We re-scaled this outcome to have a scale of 0 to 1. The reported results of the outcome compare participants in Arm A and Arm B (described in each arm/group description). For example, an intent of 0.03 indicates that participants in Arm A are 0.03 units on a scale more likely to intent to take up the flu vaccine compared to those in Arm B.

Time frame: This outcome was assessed after the video treatment during Baseline survey, which took approximately 20 minutes.

Population: Arms/Groups are combined as described in each arm/group description in order to test hypotheses prespecified in the analysis plan as well as to measure the effect of the given intervention on the outcome among the group of participants in Arm A compared to Arm B. The intervention and Arms A and B are described in each arm/group description.

ArmMeasureValue (NUMBER)
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - Black Participants(Posterior) Flu Vaccine Intent.0263281 units on a scale
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - White Participants(Posterior) Flu Vaccine Intent.0034755 units on a scale
Acknowledgement (Arm A) vs. Standard Signal (Arm B) - Black Participants(Posterior) Flu Vaccine Intent.0268659 units on a scale
Layperson Sender (Arm A) vs. Expert Sender (Arm B) - Black Participants(Posterior) Flu Vaccine Intent.0187403 units on a scale
Primary

Rating of Sender

This is an inverse-covariance-weighted index comprised of responses to survey questions regarding: 1. whether the respondent was interested in further medical advice from the given sender (measured as a binary outcome); 2. whether the respondent trusted advice from the sender measured on a scale of 1 to 5; 3. and whether the respondent's assessment of the sender's qualification to provide medical advice measured on a scale of 1 to 5. It is standardized to a mean of 0 and standard deviation of 1. Scores less than 0 indicate lower ratings of the sender rated by participants in Arm A (described in each arm/group description) compared to the rating rated by participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate higher ratings of the sender by Arm A compared to by Arm B. For example, an index score of .18 indicates that participants in Arm A rate the sender 0.18 index (in standard deviation units) higher than those in Arm B.

Time frame: This outcome was assessed during Baseline survey, which took approximately 20 minutes.

Population: Arms/Groups are combined as described in each arm/group description in order to test hypotheses prespecified in the analysis plan as well as to measure the effect of the given intervention on the outcome among the group of participants in Arm A compared to Arm B. The intervention and Arms A and B are described in each arm/group description.

ArmMeasureValue (NUMBER)
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - Black ParticipantsRating of Sender.1828917 index
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - White ParticipantsRating of Sender-.0750636 index
Acknowledgement (Arm A) vs. Standard Signal (Arm B) - Black ParticipantsRating of Sender.0997998 index
Layperson Sender (Arm A) vs. Expert Sender (Arm B) - Black ParticipantsRating of Sender-.5397662 index
Primary

Rating of Signal

This is an inverse-covariance-weighted index comprised of responses to survey questions on: 1. recommending the video to friends and family measured on a scale of 0 to 10; 2. recommending the flu shot to friends and family measured on a scale of 0 to 10; 3. and the respondent's assessment of the extent to which the information contained in the video was useful measured on a scale of 1 to 5. It is standardized to a mean of 0 and standard deviation of 1. An index score of 0 is equal to the mean. Scores less than 0 indicate lower ratings of the signal rated by participants in Arm A (described in each arm/group description) compared to the rating rated by participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate higher ratings of the signal by Arm A compared to by Arm B. For example, an index score of 0.14 indicates that participants in Arm A rate the signal 0.14 index (in standard deviation units) higher than those in Arm B.

Time frame: This outcome was assessed during Baseline survey, which took approximately 20 minutes.

Population: Arms/Groups are combined as described in each arm/group description in order to test hypotheses prespecified in the analysis plan as well as to measure the effect of the given intervention on the outcome among the group of participants in Arm A compared to Arm B. The intervention and Arms A and B are described in each arm/group description.

ArmMeasureValue (NUMBER)
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - Black ParticipantsRating of Signal.1387205 index
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - White ParticipantsRating of Signal-.0088105 index
Acknowledgement (Arm A) vs. Standard Signal (Arm B) - Black ParticipantsRating of Signal.1423725 index
Layperson Sender (Arm A) vs. Expert Sender (Arm B) - Black ParticipantsRating of Signal-.0806321 index
Primary

Safety Beliefs

This is an inverse-covariance-weighted index comprised of: 1. the point belief on the likelihood to contract the flu from the flu shot measured by a Likert scale and rescaled to have a support of -1 to 1. 2. the certainty measured with a balls and bins method and rescaled to have a support of -1 to 1. It is standardized to a mean of 0 and standard deviation of 1. An index score of 0 is equal to the mean. Scores less than 0 indicate a lower level of beliefs in the safety of flu vaccine among participants in Arm A (described in each arm/group description) compared to the level among participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate a higher level of beliefs among participants in Arm A compared to those in Arm B. For example, an index score of -0.1 indicates that participants in Arm A hold such beliefs 0.1 index (in standard deviation units) lower than those in Arm B.

Time frame: This outcome will be assessed during Baseline survey, which takes approximately 20 minutes.

Population: Arms/Groups are combined as described in each arm/group description in order to test hypotheses prespecified in the analysis plan as well as to measure the effect of the given intervention on the outcome among the group of participants in Arm A compared to Arm B. The intervention and Arms A and B are described in each arm/group description.

ArmMeasureValue (NUMBER)
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - Black ParticipantsSafety Beliefs-.0979564 index
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - White ParticipantsSafety Beliefs-.027714 index
Acknowledgement (Arm A) vs. Standard Signal (Arm B) - Black ParticipantsSafety Beliefs-.1065867 index
Layperson Sender (Arm A) vs. Expert Sender (Arm B) - Black ParticipantsSafety Beliefs-.0242752 index
Primary

Signal Content Recall

This is an inverse-covariance-weighted index comprised of responses to survey questions on: 1. whether age group for whom the flu vaccine is recommended (measured as a binary outcome); and 2. whether the flu shot contains the flu virus (recall of information discussed in the video) (measured as a binary outcome). It is standardized to a mean of 0 and standard deviation of 1. An index score of 0 is equal to the mean. Scores less than 0 indicate lower level of recalling signal content among participants in Arm A (described in each arm/group description) compared to the level among participants in Arm B (also described in each arm/group description). Scores greater than 0 indicate a higher level of recalling signal content among participants in Arm A compared to those in Arm B. For example, an index score of 0.02 indicates that participants in Arm A recall signal content 0.02 index (in standard deviation units) higher than those in Arm B.

Time frame: This outcome will be assessed during Baseline survey, which takes approximately 20 minutes.

Population: Arms/Groups are combined as described in each arm/group description in order to test hypotheses prespecified in the analysis plan as well as to measure the effect of the given intervention on the outcome among the group of participants in Arm A compared to Arm B. The intervention and Arms A and B are described in each arm/group description.

ArmMeasureValue (NUMBER)
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - Black ParticipantsSignal Content Recall-.0062555 index
Concordant (Arm A) vs. Discordant Expert Sender (Arm B) - White ParticipantsSignal Content Recall.0193832 index
Acknowledgement (Arm A) vs. Standard Signal (Arm B) - Black ParticipantsSignal Content Recall.0041984 index
Layperson Sender (Arm A) vs. Expert Sender (Arm B) - Black ParticipantsSignal Content Recall.1166304 index

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026