Colorectal Neoplasm
Conditions
Keywords
genetics, polyps, cancer, multi-gene panel
Brief summary
The study is being conducted to determine the prevalence and risk factors for germline cancer susceptibility genetic mutations among patients with advanced colorectal polyps.
Interventions
GENETICMulti-Cancer Cancer Panel
Eligible patients will receive genetic testing to determine germline cancer predisposition.
Sponsors
University of Colorado, Denver
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
* Provision to sign and date the consent form * Stated willingness to comply with all study procedures and be available for the duration of the study * Be a male or female aged 18-89 * Undergone colonoscopy * At least one advanced colorectal polyp, defined as having any of the following: * Any polyp ≥ 1cm (adenoma or serrated polyp) * Any polyp with villous architecture * Any polyp with high-grade dysplasia * Sessile serrated polyps with any dysplasia * Traditional serrated adenoma
Exclusion criteria
* Known hereditary cancer syndrome * Personal history of inflammatory bowel disease * Personal history of colorectal cancer * Polyp histology or size unavailable or not documented
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of germline pathogenic/likely pathogenic variants in cancer predisposition genes in patients with advanced colorectal polyps | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Risk factors for germline pathogenic/likely pathogenic variants in patients with advanced colorectal polyps | 3 years |
Countries
United States
Outcome results
None listed