Crohn Disease
Conditions
Brief summary
for some patients with Crohn's diseases undergoing surgery，whether exclusive enteral nutrition(EEN) could delay the disease relapse needs exploration.The trial will study whether the efficacy of postoperative EEN could help keeping remission.
Detailed description
For patients with Crohn's disease(CD), whether exclusive enteral nutrition(EEN) following bowel resection and anastomosis could delay the disease recurrence remains unkown. In this study， CD patients after surgery will be divided into two groups: one group is treated with 3 months' EEN and then turn to normal diet after 3 months; the other group is given with normal diet all through. All patients will be adminstrated with oral azathioprine after surgery. Then, the rates of 1 year postoperative endoscopic recurrence will be compared between groups.
Interventions
DIETARY_SUPPLEMENTpostoperative 3-month exclusive enteral nutrition
postoperative 3-month exclusive enteral nutrition after surgery and alter to normal food after 3 months
DRUGazathioprine
azathioprine
OTHERnormal diet
normal diet
Sponsors
Zhu Weiming
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* CD patients who undergoing bowel resection with anastomosis
Exclusion criteria
* patients who had administered with immunomodulators or biological agents patients who were created stoma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the 1 year postoperative anastomotic recurrence | 1 year | the 1 year postoperative anastomotic recurrence |
Countries
China
Contacts
Primary Contactweiming zhu
Backup Contactming duan
Outcome results
None listed