Doppler Parameters, Fetal Complications, Induction of Labor, Term Pregnancy
Conditions
Keywords
term pregnancy, Doppler parameters, Cerebroplacental ratio, Induction of labor
Brief summary
Term pregnancies within their 37-41 gestational week, who were planned to undergo induction of labor, were included in the study. Prior to initiation of the induction of labor, all included pregnant women underwent an assessment of Doppler flow indices, which included fetal umblical artery PI (pulsatility index) and fetal middle cerebral artery (MCA:Middle cerebral arter) PI. Cerebroplacental Ratio (CPR) was calculated by dividing MCA PI value to umbilical artery PI (MCA PI/UA PI=CPR).Included pregnant women were categorized as Group 1 and Group 2, which comprised of those with CPR value below 1.0 and above 1.0, respectively. Route of delivery and fetal complications, described as umbilical cord pH\<7.20, APGAR score at 5 minutes \<7, meconium aspiration syndrome, newborn intensive care unit admission, neonatal sepsis and neonatal death.
Detailed description
Term pregnancies within their 37-41 gestational week, who were planned to undergo induction of labor, were included in the study. Prior to initiation of the induction of labor, all included pregnant women underwent an assessment of Doppler flow indices, which included fetal umblical artery PI (pulsatility index) and fetal middle cerebral artery (MCA:Middle cerebral arter) PI. Cerebroplacental Ratio (CPR) was calculated by dividing MCA PI value to umbilical artery PI (MCA PI/UA PI=CPR).Included pregnant women were categorized as Group 1 and Group 2, which comprised of those with CPR value below 1.0 and above 1.0, respectively. All women who were considered appropriate for induction of labor were performed an pelvic examination and their Bishop scores were calculated. Those with a Bishop score equal to or below 5 were included in the study. Vaginal misoprostol (prostoglandin E1, 25 mcg) and dinoproston (prostoglandin E2, 10 mg) were used for induction of labor. Repeat doses were implemented in case of insufficient cervical ripening. Oxytocin was not used at the initial stages of labour, while it was used at the latter stages when necessary. Route of delivery and fetal complications, described as umbilical cord pH\<7.20, APGAR score at 5 minutes \<7, meconium aspiration syndrome, newborn intensive care unit admission, neonatal sepsis and neonatal death.
Interventions
DIAGNOSTIC_TESTDoppler flow indices assessment
Doppler flow indices, UA-PI, MCA-PI and CPR values, assessment performed prior to induction of labor
Sponsors
Istanbul Medeniyet University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Term pregnancies between 37 and 41 gestational weeks Pregnancies destined to induction of labor
Exclusion criteria
* history of uterine scar, nonverteks presentation, multiple pregnancies, use of vacuum of forceps at delivery, shoulder dystocia, confirmed fetal structural or chromosomal anomalies
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Meconium aspiration syndrome | Within postpartum two weeks | Meconium aspiration syndrome diagnosed by the pediatrician, either clinically or by thorax X-ray film. |
| Umblical arter pH | Within 1-3 minutes following delivery | Umbilical cord blood sampling just after the delivery of the newborn and pH measurement |
| APGAR score at 5 minutes | Postpartum 5 minutes | APGAR score determined by the pediatrician at postpartum 5 minutes |
| Neonatal death | Within postpartum 1 month period | Neonatal death |
| Newborn intensive care unit administration | Within postpartum 1 month period | Newborn intensive care unit administration, due to a variety of conditions, which were established by pediatrician |
| Neonatal sepsis | Within postpartum 1 month period | Neonatal sepsis diagnosed by the pediatrician |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Route of delivery | At the time of delivery | Route of delivery, either vaginally or by cesarean section |
Countries
Turkey (Türkiye)
Outcome results
None listed