Schizophrenia
Conditions
Brief summary
To investigate whether 24IU oxytocin can result in changes in functional brain connectivity in patients with schizophrenia and healthy individuals using functional magnetic resonance imaging (fMRI). The study will also examine the effect of oxytocin receptor gene polymorphism on the functional connectivity
Interventions
DRUGoxytocin
24 International units of oxytocin or palcebo will be given intranasally. The order of administration will be counterbalanced
Sponsors
National Institute of Mental Health and Neuro Sciences, India
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
After completion of clinical and cognitive assessments, all subjects will undergo a baseline fMRI scan. Later subjects will receive24IU oxytocin and saline placebo in counterbalanced order on two separate days and undergo repeat fMRI scans.
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion and
Exclusion criteria
Schizophrenia subjects: Inclusion criteria 1) Males between 18 and 50 years 2) Diagnosis of DSM-IV schizophrenia, schizoaffective or schizophreniform disorder 3) capacity to provide informed consent, as evaluated by the MacArthur Competence Assessment Tool for Clinical Research
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI changes with oxytocin | Upto 90 minutes after administration | changes in functional brain connectivity |
Countries
India
Outcome results
None listed