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Effect of Short-term Oxygen During CPET in HFpEF

Effect of Short-term Ambulatory Oxygen Therapy on Cardiopulmonary Exercise Capacity (CPET) in Patients With Heart Failure With Preserved Ejection Fraction (HFpEF)

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04157660
Enrollment
10
Registered
2019-11-08
Start date
2019-09-12
Completion date
2020-12-31
Last updated
2021-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Failure, Diastolic (HFpEF)

Brief summary

In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with heart failure with preserved ejection fraction.

Interventions

PROCEDUREOxygen application

Oxygen application Supplemental oxygen via mask

PROCEDURESham room air

Room air will be applied via mask

Sponsors

University of Zurich
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* HFpEF, stable medication for at least 4 weeks.

Exclusion criteria

* instable status, pregnancy, clinically relevant concomitant diseases, inability to follow the study procedures

Design outcomes

Primary

MeasureTime frameDescription
Work Rate (Watt)1 dayMaximal Work Rate (Watt max) measured during cardiopulmonary exercise test oxygen vs. room air
Endurance Time (s)1 dayEndurance (s) with 75% Wmax measured during cardiopulmonary exercise test oxygen vs. room air

Secondary

MeasureTime frameDescription
Changes in arterial blood parameters (pH)1 daymeasured during cardiopulmonary exercise test oxygen vs. room air
Changes in arterial blood parameters (PaO2)1 daymeasured during cardiopulmonary exercise test oxygen vs. room air
Changes in arterial blood parameters (PaCO2)1 daymeasured during cardiopulmonary exercise test oxygen vs. room air
Peak Oxygen uptake (VO2 max)1 daymeasured during cardiopulmonary exercise test oxygen vs. room air
Changes in arterial blood parameters (Bicarbonate)1 daymeasured during cardiopulmonary exercise test oxygen vs. room air
muscle tissue oxygen1 dayOxygen Saturation in the muscle measured with near-infrared spectroscopy oxygen vs. room air
cerebral tissue oxygen1 dayOxygen Saturation in the brain measured with near-infrared spectroscopy oxygen vs. room air
Changes in arterial blood parameters (Lactat)1 daymeasured during cardiopulmonary exercise test oxygen vs. room air
Respiratory Exchange Ratio (RER)1 daymeasured during cardiopulmonary exercise test oxygen vs. room air

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026