Heart Failure
Conditions
Brief summary
Researchers are trying learn more about how the heart and blood volume interact in subjects with heart failure and how measuring blood volume may help them develop better ways of treating and managing heart failure patients.
Interventions
DIAGNOSTIC_TESTQuantitated Blood Volume Analysis
Measurement of total blood volume, composed of red blood cell mass (RBCM) and plasma volume (PV) by administering low dose iodinated I-131 labeled albumin intravenously then taking blood samples at timed increments.
Sponsors
Mayo Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Acute Decompensated Chronic Heart Failure, diagnosed clinically with volume overload by the primary Heart Failure provider or Emergency Department physician and admitted to hospital. * New York Hear Association functional class III-IVa with stage C or D Heart Failure with Left Ventricular Ejection Fraction \<50% * Intended treatment plan with intravenous loop diuretic therapy during hospitalization * Meeting none of the
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in total blood volume | Baseline, 1 month, 3 month, and 6 month | Measured in milliliters |
| Change in red blood cell volume | Baseline, 1 month, 3 month, and 6 month | Measured in milliliters |
| Change in plasma volume | Baseline, 1 month, 3 month, and 6 month | Measured in milliliters |
Countries
United States
Outcome results
None listed