Muscle Recovery
Conditions
Keywords
Muscle Strength, Musculoskeletal Physiology, Muscle, Skeletal, Whey Proteins, Plant Proteins, Dietary supplements
Brief summary
This study will assess the effect of daily post-exercise vegan (pea) and animal (whey) protein ingestion compared to placebo over 7 days of recovery from strenuous exercise. Muscle strength and soreness will be measured daily, and mechanisms underpinning recovery will be investigated in muscle biopsies taken 3, 24 and 48 hours after exercise.
Detailed description
Strenuous exercise can cause muscle soreness and reduced muscle strength. It is widely acknowledged that nutritional supplements derived from animal protein sources, including whey from milk, aids recovery when taken immediately after strenuous exercise. However, the effect of vegan protein supplements are less understood, and how they affect recovery of strength and soreness is not known. This is an important area of research due to the increasing demand for plant-based protein.
Interventions
DIETARY_SUPPLEMENTRecovery animal (20g whey) protein supplement
Animal protein supplement consumed post exercise to aid recovery of muscle function following strenuous exercise.
DIETARY_SUPPLEMENTRecover vegan (26g pea) protein supplement
Vegan protein supplement consumed post exercise to aid recovery of muscle function following strenuous exercise.
DIETARY_SUPPLEMENTPlacebo (32g maltodextrin)
Placebo consumed post exercise to aid recovery of muscle function following strenuous exercise.
Sponsors
Beachbody
University of Exeter
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Recreationally active * 18-40 years of age
Exclusion criteria
* Regular and structured involvement in resistance training * Inactive participants * Habitual dietary protein intake \<0.8g/kg bw/day and \>2.0g/kg bw/day * Use of nutritional supplements * Any diagnosed metabolic conditions (diabetes), cardiovascular disease or hypertension * Current musculoskeletal injury * Use of anti-inflammatory medicines * Individuals with non -removable metallic implants (including heart pacemaker, cochlea implants, medication pumps, surgical clips, plates or screws) or claustrophobia * Individuals with an allergy to egg, fish, wheat or soy ingredients as the product is manufactured in a facility that contains these ingredients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in isokinetic work (W30) performed before and every 24 h after performing 300 maximal eccentric quadriceps contractions. | Once per 24 hour period for 7 days | The recovery of skeletal muscle isokinetic force production following eccentric exercise using an isokinetic dynamometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Perceived quadriceps muscle soreness | Once per 24 hour period for 7 days | Soreness will be assessed using a visual analogue scale (VAS) to determine whether the protein supplement can reduce muscle soreness following eccentric exercise. This scale will represent a 100mm line with no pain and worst pain anchored at either end of the scale. |
| Muscle swelling | Once per 24 hour period for 3 days | Determine whether the protein supplement can reduce muscle swelling following eccentric exercise assessed using MRI |
| Rate of protein incorporation into the muscle | Once per 24 hour period for 3 days | Determine whether the strenuous exercise and a protein supplement can upregulate protein synthesis following strenuous exercise assessed by muscle biopsies |
| Plasma creatine kinase (CK) activity before and every 24 h after performing 300 maximal eccentric quadriceps contractions. | Once per 24 hour period for 7 days | Damage and inflammatory bio markers following strenuous exercise assessed by blood sample |
| Change in flow mediated dilation | Once hourly post exercise for 3 hours | Determine whether the protein polyphenol supplement can impact vascular function following eccentric exercise |
Countries
United Kingdom
Outcome results
None listed