HFNC vs NPPV After Early Extubation for Patients With COPD

High-flow Nasal Cannula Versus Noninvasive Positive Pressure Ventilation Therapy After Early Extubation for Patients With Chronic Obstructive Pulmonary Disease

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04156139

Enrollment

502

Registered

2019-11-07

Start date

2019-12-18

Completion date

2022-11-01

Last updated

2020-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, Hypercapnic Respiratory Failure

Keywords

NPPV, HFNC, Weaning, COPD, PIC

Brief summary

High-flow nasal cannula oxygen therapy(HFNC) has proved no significant difference compared with noninvasive positive pressure ventilation (NPPV) in preventing postextubation respiratory failure and reintubation in patients with acute hypoxemic respiratory failure.However, the efficacy of early postextubation sequential HFNC in COPD patients with hypercapnic respiratory failure is inconclusive.

Detailed description

The investigators conducted this prospective randomized controlled trial to explore the efficacy, safety of HFNC versus NPPV after early extubation in COPD patients with hypercapnic respiratory failure.The investigators hypothesized that the efficacy of HFNC after early extubation is non-inferior to that of NPPV.

Interventions

DEVICEHFNC

The gas flow rate was set at 45\ 55 L/min. The inhaled oxygen concentration will be dynamically adjusted to maintain SpO2 ≥ 92%. The temperature will be set at 37 °C.

DEVICENPPV

The PEEP is initially set as 5 cm H2O, the inspiratory pressure is 10 cm H2O, and the target tidal volume is 6-8 ml/kg.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 85 Years

Healthy volunteers

Inclusion criteria

* 1\. COPD patients with bronchopulmonary infection 2. Patients with hypercapnia respiratory failure treated with invasive mechanical 3.14 days ≥ invasive mechanical ventilation ≥ 48 hours; 4.Reached the pulmonary infection control (PIC) window; 5.Have self-care ability with oxygen supply during stable phrase

Exclusion criteria

* Severe organ dysfunction;Myopathy or myasthenia gravis;Upper airway obstruction;A large amount of secretions and inability to drain;

Design outcomes

Primary

Measure	Time frame	Description
reintubation	within the 7 days after extubation.	The primary outcome is reintubation within the 7 days after extubation.

Secondary

Measure	Time frame	Description
Weaning failure	within the7 days after extubation	Secondary Outcome is a composite criterion including reintubation events or all-cause deaths within the7 days after extubation

Countries

China

Contacts

Primary ContactHan Xiaobo, MD

hansir510@163.com+86 18600310765

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026