Neuropathy Demyelinating
Conditions
Keywords
Gait, Balance, Posture, Charcot-Marie-Tooth, Chronic inflammatory demyelinating polyneuropathy
Brief summary
If the classification between hereditary and acquired neuropathy is often easy, there is no completely specific marker allowing the distinction between the two etiologies. Clinical experience suggests that hereditary neuropathies have less impact on balance and gait than the acquired neuropathies at equivalent level of impairment, but this has never been clearly demonstrated.
Interventions
OTHERMotion analysis
Gait and posture recording
Sponsors
University Hospital, Lille
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* CMT1A for molecular-proven Group 1 (PMP22 duplication) * IPDC likely or defined for Group 2 * Able to walk 10 m unassisted
Exclusion criteria
* Neurological history other than neuropathy: epilepsy, stroke, dementia * Pregnant women * Person under guardianship or trusteeship * Musculoskeletal conditions other than neuropathy impairing walking abilities * Major comorbidity considered a contraindication by the investigator (cancer, unstable angor, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Posturography (Romberg's quotient) | Time 0 ; single session |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The Timed Up and Go test (TUG) | Time 0 ; single session | It uses the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down. the scores of ten seconds or less indicate normal mobility, 11-20 seconds are within normal limits for frail elderly and disabled patients, and greater than 20 seconds means the person needs assistance outside and indicates further examination and intervention. A score of 30 seconds or more suggests that the person may be prone to falls |
| stride length (in millimeters) parameters | Time 0 ; single session | Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®) |
| stride time (in seconde) parameters | Time 0 ; single session | Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®) |
| velocity (meter/seconde) parameters | Time 0 ; single session | Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®) |
| cadence (step/min) parameters | Time 0 ; single session | Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®) |
Countries
France
Outcome results
None listed