Middle Aged Patients
Conditions
Brief summary
Our study is designed to evaluate the effect of intranasal insulin on postoperative cognitive dysfunction. Primary outcome: 1\. The occurrence of cognitive dysfunction at approximately 7 days after surgery. Secondary outcome: 1\. Incidence of any side effect.
Interventions
DRUGIntranasal insulin
Surgical group Received intranasal insulin, the second group surgical Received placebo and the third group is non surgical do not receive anything.
Sponsors
Minia University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age 40 - 60 years. 2. Both gender. 3. Patients will be scheduled for elective major abdominal, thoracic, orthopedic, open gynecological, open urological, spine, otolaryngological surgeries under general anesthesia with expected hospital stay \>4 days.
Exclusion criteria
* 1\. Drug allergy. 2. Patients with major psychiatric disease. 3. Patients receive major tranquillizers and antidepressant. 4. Those undergoing neurosurgery or cardiac surgery. 5. Those unable or unwilling to abide by the study procedure 6. Those who could not follow procedure or who had poor comprehension of dutch language. 7. Those with sever visual and auditory disorder / handicaps.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive dysfunction | 7 days | The occurrence of cognitive dysfunction at approximately 7 days after surgery. |
Countries
Egypt
Contacts
Primary ContactNourhan Mohamed Anter
Outcome results
None listed