Coronary Artery Disease
Conditions
Brief summary
The coronary images of invasive angiography and optical coherence tomography (or Coronary CT angiography) with FFR(Fractional Flow Reserve) values of the intermediate lesions (50-70% stenosis) will be prospectively registered.
Interventions
OTHEROCT, coronary angiography, FFR
Coronary images by OCT and angiography and FFR values will be registered.
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Patients who underwent coronary CT angiography because of chest pain 2. Patients who need OCT or FFR evaluation because of intermediate lesions according to invasive angiography (diameter stenosis of 50-70%) 3. Age: 20-80 yrs 4. Patients who consent and fully understand the protocol 5. Patients who consent the clinical follow-up 6. Patients who can be followed-up
Exclusion criteria
1. Patients who had contrast allergy 2. Patients who had unstable blood pressure needing the vasopressors 3. Patients who had severe left ventricular function (left ventricular ejection fraction\<30%) 4. Chronic kidney disease who had Cr level of greater than 2.0 mg/dl 5. Patients whose expected survival is less than 12 months 6. Patients who had a severe valvular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of computed FFR derived by coronary images and real FFR values | at registration | FFR values computed by OCT/CT/invasive coronary angiography will be compared by real invasive FFR values |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Adverse event (Death, acute myocardial infarction) | 2 years after registration | Death and occurrence of myocardial infarction during follow-up period will be assessed. |
Countries
South Korea
Outcome results
None listed