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Estimating Premorbid Intellectual Functioning in Children and Measuring Change in Cognitive Functioning as Children Develop

Estimating Premorbid Intellectual Functioning in the Paediatric Population and Developing a Reliable Means for Quantifying Abnormal Change in Cognitive Functions as Children Develop

Status
Enrolling by invitation
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04153838
Enrollment
100
Registered
2019-11-06
Start date
2019-10-31
Completion date
2026-12-01
Last updated
2026-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Child Development, Cognitive Impairment

Keywords

Neuropsychology

Brief summary

Diagnosing and documenting the presence of abnormal change in cognitive functions (such as reasoning abilities) in children over time is of upmost importance when it comes to evaluating the impact of neurological injury, disease, and interventions designed to help improve wellbeing. Unfortunately however, current methods for detecting cognitive impairment and monitoring for abnormal cognitive change in children over time are seriously flawed. By assessing typically developing children's cognitive functioning at two different time points, this study intends to generate new normative data that will significantly improve measurement accuracy when it comes to evaluating the impact of neurological injury and disease on a child's cognitive abilities.

Detailed description

Neurological injury and disease can substantially affect how children's brains work. This can severely impair cognitive abilities and general development. On a day-to-day level, completing everyday tasks, socialising successfully with peers, and getting on with school work can become much more difficult than it was before. Helpfully, supports and treatments are available that can reduce the negative effects of neurological impairment on a child's cognitive functioning in order to maximise developmental outcomes. However, to deliver appropriate interventions, we must correctly estimate the impact of injury or illness on cognitive abilities and accurately measure how successful treatments are at improving outcomes. Unfortunately, reliable ways of doing this simply do not exist at this time. Consequently, accurate disease (effects) monitoring is seriously undermined; potentially compromising a child's medical management and, thereby, future developmental outcomes. This study intends to addresses this grave shortcoming by developing reliable ways of measuring the cognitive effects of neurological disease or injury at diagnosis and beyond. Of note, by providing a mechanism to better inform clinical/medical management decisions, completion of this study will help contribute to health and social care aims of enabling children to realise their developmental potential.

Interventions

OTHERCognitive test administration

Specifically chosen cognitive tests will be administered to all participants twice; with an approximate 12 month gap between initial testing and follow-up testing.

Sponsors

University of Aberdeen
Lead SponsorOTHER
NHS Grampian
CollaboratorOTHER_GOV

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
6 Years to 17 Years
Healthy volunteers
Yes

Inclusion criteria

* All participants must be aged between 6 years 0 months and 16 years 11 months 364 days * Participants must be enrolled into a local mainstream school and have English as their first language * Participants must not have sustained a previous brain-injury and not suffer from any other neurological illness (please see

Exclusion criteria

below)

Design outcomes

Primary

MeasureTime frameDescription
Obtained intelligence quotient (IQ) scoreBaselineA child's obtained Full Scale IQ score from a standardised assessment of intelligence constitutes the main outcome variable for this study
Change in obtained intelligence quotient (IQ) score (at 12 month follow-up)12 monthsA child's obtained Full Scale IQ score at 12 months follow-up also constitutes a main outcome variable for this study

Countries

United Kingdom

Contacts

PRINCIPAL_INVESTIGATORBruce Downey

NHS Grampian

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 7, 2026